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播散性感染由 Scedosporium/Lomentospora 在急性髓细胞白血病并发非结核分枝杆菌诱导治疗期间。

Disseminated Infection by Scedosporium/Lomentospora during Induction Therapy for Acute Myeloid Leukemia Complicated by Nontuberculous Mycobacteria.

机构信息

Department of Hematology, Nagano Red Cross Hospital, Japan.

Department of Medical Mycology Research Center, Chiba University, Japan.

出版信息

Intern Med. 2024 May 15;63(10):1465-1471. doi: 10.2169/internalmedicine.2159-23. Epub 2023 Oct 13.

DOI:10.2169/internalmedicine.2159-23
PMID:37839883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11157310/
Abstract

Scedosporium/Lomentospora infections are rare and are associated with a high mortality rate in immunocompromised patients. A 69-year-old man with nontuberculous mycobacteria (NTM) died during induction chemotherapy for acute myeloid leukemia because of multiple organ failure due to pneumonia. During an autopsy, Lomentospora prolificans was detected using a fungal gene analysis of the blood, lungs, spleen, kidneys, and intestines, and Scedosporium aurantiacum was detected in the lungs. NTM disease may predispose patients to Scedosporium/Lomentospora infections. Physicians should consider Scedosporium/Lomentospora spp. as an invasive fungal infection that occurs during myelosuppression, particularly when NTM is a complication.

摘要

节菱孢霉/枝顶孢霉感染较为罕见，但在免疫功能低下的患者中与高死亡率相关。一名 69 岁男性因非结核分枝杆菌（NTM）感染而死于急性髓系白血病诱导化疗期间，其死于肺炎导致的多器官衰竭。尸检时，通过血液、肺、脾、肾和肠的真菌基因分析检测到繁茂枝顶孢霉，并且在肺部检测到橘青霉。NTM 疾病可能使患者易患节菱孢霉/枝顶孢霉感染。当 NTM 是并发症时，医生应将节菱孢霉/枝顶孢霉属视为骨髓抑制期间发生的侵袭性真菌感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20e2/11157310/80475969b2c3/1349-7235-63-1465-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20e2/11157310/567ecd7f530f/1349-7235-63-1465-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20e2/11157310/c7edcf393a5a/1349-7235-63-1465-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20e2/11157310/7a7921332c68/1349-7235-63-1465-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20e2/11157310/80475969b2c3/1349-7235-63-1465-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20e2/11157310/567ecd7f530f/1349-7235-63-1465-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20e2/11157310/c7edcf393a5a/1349-7235-63-1465-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20e2/11157310/7a7921332c68/1349-7235-63-1465-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20e2/11157310/80475969b2c3/1349-7235-63-1465-g004.jpg

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本文引用的文献

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Br J Haematol. 2022 Apr;197(1):63-70. doi: 10.1111/bjh.18051. Epub 2022 Feb 16.
2
Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology.罕见霉菌感染诊断与管理全球指南：欧洲医学真菌学联合会与国际人类与动物真菌学会及美国微生物学会合作发起
Lancet Infect Dis. 2021 Aug;21(8):e246-e257. doi: 10.1016/S1473-3099(20)30784-2. Epub 2021 Feb 16.
3
Comparison of Antifungal Prophylaxis Drugs in Patients With Hematological Disease or Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review and Network Meta-analysis.血液病或造血干细胞移植患者抗真菌预防药物的比较：系统评价和网络荟萃分析。
JAMA Netw Open. 2020 Oct 1;3(10):e2017652. doi: 10.1001/jamanetworkopen.2020.17652.
4
Antifungal Susceptibility Profiles and Drug Resistance Mechanisms of Clinical Lomentospora prolificans Isolates.临床多育卷枝毛霉分离株的抗真菌药敏谱及耐药机制
Antimicrob Agents Chemother. 2020 Oct 20;64(11). doi: 10.1128/AAC.00318-20.
5
Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia.阿扎胞苷和维奈托克治疗未经治急性髓系白血病。
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6
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7
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8
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10
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