Servicio de Reumatología, Hospital del Mar, Barcelona, Spain.
Unidad de Investigación, Sociedad Española de Reumatología, Madrid, Spain.
Reumatol Clin (Engl Ed). 2023 Nov;19(9):465-477. doi: 10.1016/j.reumae.2023.07.003. Epub 2023 Oct 13.
To develop evidence-based expert-consensus recommendations for the management of non-infectious, non-neoplastic, non-demyelinating disease associated uveitis.
Clinical research questions relevant to the objective of the document were identified, and reformulated into PICO format (patient, intervention, comparison, outcome) by a panel of experts selected based on their experience in the field. A systematic review of the available evidence was conducted, and evidence was graded according to GRADE (Grading of Recommendations Assessment, Development, and Evaluation) criteria. Subsequently, recommendations were developed.
Three PICO questions were constructed referring to uveitis anterior, non-anterior and complicated with macular edema. A total of 19 recommendations were formulated, based on the evidence found and/or expert consensus.
Here we present the first official recommendations of the Spanish Society of Rheumatology for the treatment of non-infectious and non-demyelinating disease associated uveitis. They can be directly applied to the Spanish healthcare system as a tool for assistance and therapeutic homogenisation.
为非感染性、非肿瘤性、非脱髓鞘性疾病相关葡萄膜炎的治疗制定基于循证医学的专家共识建议。
根据专家组在该领域的经验，选择专家组成员，将与本文档目标相关的临床研究问题重新制定为 PICO 格式（患者、干预、对照、结局）。对现有证据进行系统回顾，并根据 GRADE（推荐评估、制定与评价）标准对证据进行分级。随后制定建议。
针对前葡萄膜炎、非前葡萄膜炎和合并黄斑水肿这三种葡萄膜炎，共构建了 3 个 PICO 问题。根据发现的证据和/或专家共识，共制定了 19 条建议。
本文提出了西班牙风湿病学会针对非感染性和非脱髓鞘性疾病相关葡萄膜炎治疗的首份官方建议。它们可直接应用于西班牙医疗保健系统，作为辅助和治疗同质化的工具。
