Drain Ben A, Becer Remzi C
Department of Chemistry, University of Warwick, Coventry, UK.
School of Engineering and Materials Science, Queen Mary University of London, London, UK.
Des Monomers Polym. 2023 Oct 11;26(1):214-222. doi: 10.1080/15685551.2023.2267232. eCollection 2023.
Partially hydrolysed poly(2-oxazoline)s possess unique properties. However, much of the focus in this area has been on water soluble poly(2-oxazoline)s. Where hydrophobic poly(2-oxazoline)s have been used, this is often for selective hydrolysis. However, hydrolysis of very hydrophobic polymers could lead to interesting solution behaviour. Herein, we describe universal conditions for the hydrolysis of poly(2-alkyl-2-oxazoline)s suitable for both hydrophobic and hydrophilic 2-oxazolines. We show that the system utilised gives comparable rates to that of water alone for poly(2-ethyl-2-oxazoline). In addition, poly(2-fatty acid-2-oxazoline) was hydrolysed using the developed system and was found to proceed in a controlled manner allowing the targeting of specific degrees of hydrolysis, albeit much slower than for poly(2-ethyl-2-oxazoline). Finally, we demonstrate the partial functionalisation of poly(2-oxazoline)-poly(ethylene imine) co-polymers aza-Michael addition.
部分水解的聚（2-恶唑啉）具有独特的性能。然而，该领域的大部分研究重点都集中在水溶性聚（2-恶唑啉）上。当使用疏水性聚（2-恶唑啉）时，通常是用于选择性水解。然而，非常疏水的聚合物的水解可能会导致有趣的溶液行为。在此，我们描述了适用于疏水性和亲水性2-恶唑啉的聚（2-烷基-2-恶唑啉）水解的通用条件。我们表明，所使用的体系对于聚（2-乙基-2-恶唑啉）的水解速率与单独用水时相当。此外，使用所开发的体系对聚（2-脂肪酸-2-恶唑啉）进行水解，发现其以可控方式进行，能够实现特定水解度的目标，尽管比聚（2-乙基-2-恶唑啉）的水解要慢得多。最后，我们展示了聚（2-恶唑啉）-聚（乙烯亚胺）共聚物的部分官能化——氮杂-Michael加成反应。
