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将辐射个性传递给后代(TRIO)研究:调查代际传递对大脑发育的影响。

Transmit Radiant Individuality to Offspring (TRIO) study: investigating intergenerational transmission effects on brain development.

作者信息

Matsudaira Izumi, Yamaguchi Ryo, Taki Yasuyuki

机构信息

Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.

Smart-Aging Research Center, Tohoku University, Sendai, Japan.

出版信息

Front Psychiatry. 2023 Sep 28;14:1150973. doi: 10.3389/fpsyt.2023.1150973. eCollection 2023.

Abstract

Intergenerational transmission is a crucial aspect of human development. Although prior studies have demonstrated the continuity of psychopathology and maladaptive upbringing environments between parents and offspring, the underlying neurobiological mechanisms remain unclear. We have begun a novel neuroimaging research project, the Transmit Radiant Individuality to Offspring (TRIO) study, which focuses on biological parent-offspring trios. The participants of the TRIO study were Japanese parent-offspring trios consisting of offspring aged 10-40 and their biological mother and father. Structural and functional brain images of all participants were acquired using magnetic resonance imaging (MRI). Saliva samples were collected for DNA analysis. We obtained psychosocial information, such as intelligence, mental health problems, personality traits, and experiences during the developmental period from each parent and offspring in the same manner as much as possible. By April 2023, we completed data acquisition from 174 trios consisting of fathers, mothers, and offspring. The target sample size was 310 trios. However, we plan to conduct genetic and epigenetic analyses, and the sample size is expected to be expanded further while developing this project into a multi-site collaborative study in the future. The TRIO study can challenge the elucidation of the mechanism of intergenerational transmission effects on human development by collecting diverse information from parents and offspring at the molecular, neural, and behavioral levels. Our study provides interdisciplinary insights into how individuals' lives are involved in the construction of the lives of their descendants in the subsequent generation.

摘要

代际传递是人类发展的一个关键方面。尽管先前的研究已经证明了父母与子女之间精神病理学和适应不良养育环境的连续性,但其潜在的神经生物学机制仍不清楚。我们已经启动了一个新的神经影像学研究项目,即“将光芒四射的个性传递给后代”(TRIO)研究,该研究聚焦于亲生父母与子女三人组。TRIO研究的参与者是日本亲生父母与子女三人组,子女年龄在10至40岁之间,其亲生父母为父亲和母亲。使用磁共振成像(MRI)获取了所有参与者的大脑结构和功能图像。收集唾液样本用于DNA分析。我们以尽可能相同的方式从每位父母和子女那里获取了心理社会信息,如智力、心理健康问题、人格特质以及发育时期的经历。到2023年4月,我们完成了对174个由父亲、母亲和子女组成的三人组的数据采集。目标样本量为310个三人组。然而,我们计划进行基因和表观遗传分析,并且在未来将该项目发展成为一项多中心合作研究的过程中,样本量预计会进一步扩大。TRIO研究可以通过在分子、神经和行为层面从父母和子女那里收集多样化信息,来挑战对代际传递影响人类发展机制的阐释。我们的研究为个体的生活如何参与到其后代下一代生活的构建中提供了跨学科的见解。

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