Wei Cunsheng, Yu Xiaorong, Chen Yuan, Yang Tingting, Li Shenghua, Li Junrong, Chen Xuemei
Department of Neurology, Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, Jiangsu, 211100, People's Republic of China.
Int J Gen Med. 2023 Oct 10;16:4585-4593. doi: 10.2147/IJGM.S434968. eCollection 2023.
Studies have shown that severe coronavirus pandemic 2019 infection could lead to white matter hyperintensities, but the relationship between asymptomatic/mild illness and moderate illness coronavirus pandemic 2019 and white matter hyperintensities remains largely unknown. This study aimed to investigate the relationship between asymptomatic/mild illness and moderate illness coronavirus pandemic 2019 and the risk of white matter hyperintensities.
Hospitalized patients who were confirmed to have coronavirus pandemic 2019 for the first time were enrolled. Fazekas scores were used for assessment of the severity of white matter hyperintensities. We also rated the 90-day functional outcome after discharge.
Of the 157 enrolled patients, 124 (78.98%) coronavirus pandemic 2019 patients were classified as having asymptomatic or mild illness, and 33 (21.02%) were classified as having moderate illness. The results showed that the Fazekas scale scores at baseline (periventricular white matter hyperintensities, 1.31±1.16 vs 2.06±1.20; Deep white matter hyperintensities, 1.04±0.97 vs 1.73±1.13 <0.01) and at follow-up (periventricular white matter hyperintensities, 1.38±1.21 vs 2.09±1.21; Deep white matter hyperintensities, 1.13±1.04 vs 1.79±1.14 <0.01) were lower in patients with symptomatic or mild illness than in those with moderate illness. Moreover, no significant difference (7.26% vs 3.03%; =0.377) was observed between the two divided groups in terms of white matter hyperintensities progression.
Our findings suggest that moderate COVID-19 is related to severe white matter hyperintensities compared with asymptomatic/mild illness but not to the progression of white matter hyperintensities.
研究表明，2019年冠状病毒大流行严重感染可导致白质高信号，但无症状/轻症与中症2019年冠状病毒病大流行和白质高信号之间的关系仍 largely unknown。本研究旨在探讨无症状/轻症和中症2019年冠状病毒病大流行与白质高信号风险之间的关系。
纳入首次确诊为2019年冠状病毒病大流行的住院患者。采用 Fazekas 评分评估白质高信号的严重程度。我们还对出院后90天的功能结局进行了评分。
在纳入的157例患者中，124例（78.98%）2019年冠状病毒病大流行患者被分类为无症状或轻症，33例（21.02%）被分类为中症。结果显示，有症状或轻症患者在基线时（脑室周围白质高信号，1.31±1.16 对 2.06±1.20；深部白质高信号，1.04±0.97 对 1.73±1.13 <0.01）和随访时（脑室周围白质高信号，1.38±1.21 对 2.09±1.21；深部白质高信号，1.13±1.04 对 1.79±1.14 <0.01）的 Fazekas 量表评分低于中症患者。此外，两组在白质高信号进展方面未观察到显著差异（7.26% 对 3.03%； =0.377）。
我们的研究结果表明，与无症状/轻症相比，中症新型冠状病毒肺炎与严重白质高信号有关，但与白质高信号的进展无关。
