Feichtinger Stuart, Lazar Angela A, Luebbe Megan A, Accola Molly A, Jung-Hynes Brittney D, Anderson Patti J, Koglin Kelly M, Schliesman Karen S, Ehlenbach William, Smith Jeannina, Chen Derrick J, Rehrauer William M, Bailey Adam L
Department of Anesthesiology, Division of Critical Care, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
University of Wisconsin Hospitals and Clinics, Clinical Laboratories, Madison, WI, USA.
Access Microbiol. 2023 Sep 19;5(9). doi: 10.1099/acmi.0.000533.v4. eCollection 2023.
A patient suffered a non-fatal wet drowning in a freshwater lake and developed bacteraemia several days later. Blood culture grew a Gram-negative rod that could not be identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). 16S ribosomal RNA sequencing of the isolate identified the microbe as - an environmental microbe commonly found in freshwater. The recovery of multiple pathogenic micro-organisms (although not ) from culture of respiratory specimens prompted the initiation of antibiotic therapy with cefepime and, later, vancomycin. The patient's clinical course gradually improved over the course of 2 weeks and she was ultimately discharged home with minimal sequelae. To our knowledge, this is the first evidence of human infection with bacteria in the genus . may be considered in cases of freshwater near-drowning, and MALDI-TOF MS databases should be updated to include .
一名患者在淡水湖中发生非致命性溺水,数天后出现菌血症。血培养生长出一株革兰氏阴性杆菌,基质辅助激光解吸/电离飞行时间质谱(MALDI-TOF MS)无法鉴定该菌。对分离株进行16S核糖体RNA测序,确定该微生物为——一种常见于淡水中的环境微生物。从呼吸道标本培养物中检出多种致病微生物(尽管不是 ),促使开始使用头孢吡肟治疗,随后使用万古霉素。患者的临床病程在2周内逐渐改善,最终出院,后遗症极少。据我们所知,这是首例人类感染该属细菌的证据。在淡水近乎溺水的病例中可考虑 ,MALDI-TOF MS数据库应更新以纳入 。