Leung R J, Rao N A
Jpn J Ophthalmol. 1986;30(3):288-97.
Specific immunohistochemical localization of lactate dehydrogenase (LDH isoenzyme 1) in well-differentiated retinoblastomas revealed the presence of this enzyme predominantly in the cytoplasm of cells that form Flexner-Wintersteiner and Homer Wright rosettes. Malignant cells of poorly differentiated retinoblastomas also contained the reaction product for LDH, but the intensity of the reaction was much less. LDH was also present in the corneal epithelium, corneal endothelium, ciliary muscle, nonpigmented ciliary epithelium, iris muscle, lens epithelium, lens cortex, pigment epithelium and the neurosensory retina. This specific immunohistochemical localization revealed distribution of this enzyme primarily in those ocular structures that have a relatively high rate of metabolism, as well as in various cellular components of retinoblastomas.
乳酸脱氢酶（LDH同工酶1）在高分化视网膜母细胞瘤中的特异性免疫组织化学定位显示，该酶主要存在于形成Flexner-Wintersteiner和Homer Wright菊形团的细胞胞质中。低分化视网膜母细胞瘤的恶性细胞也含有LDH的反应产物，但反应强度要小得多。LDH也存在于角膜上皮、角膜内皮、睫状肌、无色素睫状上皮、虹膜肌、晶状体上皮、晶状体皮质、色素上皮和神经感觉视网膜中。这种特异性免疫组织化学定位显示，该酶主要分布在代谢率相对较高的眼部结构以及视网膜母细胞瘤的各种细胞成分中。
