Bavia Paula Furlan, Khawaja Shehryar, Hernández-Nuño de la Rosa María F, Tseng Lisa A, Keith David Alexander
Private Practice Boca Raton Prosthodontics (Practice Limited to Orofacial Pain), Boca Raton, FL, USA.
Department of Internal Medicine, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore, Pakistan.
J Pain Res. 2023 Oct 10;16:3433-3440. doi: 10.2147/JPR.S412459. eCollection 2023.
Sleep impairment is associated with many chronic pain disorders. While there is an association between chronic pain and sleep disturbances, little is known about the influence of pharmacotherapy for chronic pain conditions, particularly chronic opioid therapy, on sleep. This study aimed to 1) compare the sleep quality (SQ) in patients with two different pain conditions-chronic body pain and chronic orofacial pain; 2) assess the correlation of SQ and pain intensity; and 3) evaluate the association between pharmacotherapy and SQ.
The Pittsburgh Sleep Quality Index (PSQI) was used to measure the SQ in subjects with 1) chronic body pain (n = 100) and 2) chronic orofacial pain (n = 100). The visual analogue scale was applied for pain intensity rating. All subjects were adults recruited at Massachusetts General Hospital, United States. The subjects' demographic data, pain intensity, diagnosis and concurrent use of medications were extracted from their electronic medical records (EMR). Statistical analyses were performed using -test and Pearson correlation coefficient.
Among 200 subjects (mean age 51.01 ± 15.52 years), 141 (70.5%) were females. PSQI and pain intensity were statistically significantly different between the two groups (p < 0.05 and p < 0.0001, respectively) and higher in subjects with chronic body pain. There was a positive correlation between PSQI and pain intensity (chronic orofacial pain r = 0.3535, p = 0.0004; chronic body pain: r = 0.2247, p < 0.026). PSQI was higher in chronic orofacial pain subjects utilizing opioids and benzodiazepines (PSQI = 15.25).
Chronic pain impairs SQ, which is noticeably worse in subjects with body pain conditions. In addition, pain intensity was correlated with poorer SQ, which in turn was linked to the concomitant use of opioid and benzodiazepine therapy in chronic orofacial pain.
睡眠障碍与多种慢性疼痛疾病相关。虽然慢性疼痛与睡眠障碍之间存在关联，但对于慢性疼痛疾病的药物治疗，尤其是慢性阿片类药物治疗对睡眠的影响知之甚少。本研究旨在：1）比较患有两种不同疼痛疾病——慢性身体疼痛和慢性口面部疼痛的患者的睡眠质量（SQ）；2）评估睡眠质量与疼痛强度的相关性；3）评估药物治疗与睡眠质量之间的关联。
匹兹堡睡眠质量指数（PSQI）用于测量以下两类受试者的睡眠质量：1）慢性身体疼痛患者（n = 100）和2）慢性口面部疼痛患者（n = 100）。采用视觉模拟量表进行疼痛强度评分。所有受试者均为在美国马萨诸塞州总医院招募的成年人。受试者的人口统计学数据、疼痛强度、诊断及同时使用的药物均从其电子病历（EMR）中提取。使用t检验和Pearson相关系数进行统计分析。
在200名受试者（平均年龄51.01±15.52岁）中，141名（70.5%）为女性。两组之间的PSQI和疼痛强度在统计学上有显著差异（分别为p < 0.05和p < 0.0001），且慢性身体疼痛患者的数值更高。PSQI与疼痛强度之间存在正相关（慢性口面部疼痛：r = 0.3535，p = 0.0004；慢性身体疼痛：r = 0.2247，p < 0.026）。使用阿片类药物和苯二氮䓬类药物的慢性口面部疼痛受试者的PSQI更高（PSQI = 15.25）。
慢性疼痛会损害睡眠质量，在身体疼痛患者中情况明显更糟。此外，疼痛强度与较差的睡眠质量相关，而这又与慢性口面部疼痛中同时使用阿片类药物和苯二氮䓬类药物治疗有关。
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