Maeda K, Tanimoto K, Terada T
Jpn J Psychiatry Neurol. 1986 Jun;40(2):227-30. doi: 10.1111/j.1440-1819.1986.tb03145.x.
The effect of a chronic lithium treatment on the [3H]-imipramine binding in rat brain regions was investigated. In the striatum, an oral administration of lithium for 30 days induced a decrease in the [3H]-imipramine binding at the concentration of [3H]-imipramine, 1.0 nM, compared to the control. Lithium did not affect the [3H]-imipramine binding in the cerebral cortex and hypothalamus. A Scatchard analysis in the striatum revealed a decrease in the number of [3H]-imipramine binding sites with no changes in the binding affinity. These results suggest that the chronic lithium treatment may produce subsensitivity of the [3H]-imipramine binding in man and that this effect of the ion may be closely related to the established effect of lithium in the treatment of affective disorders.
研究了慢性锂治疗对大鼠脑区[³H]-丙咪嗪结合的影响。在纹状体中，与对照组相比，口服锂30天可使[³H]-丙咪嗪浓度为1.0 nM时的[³H]-丙咪嗪结合减少。锂对大脑皮质和下丘脑的[³H]-丙咪嗪结合无影响。纹状体的Scatchard分析显示[³H]-丙咪嗪结合位点数量减少，结合亲和力无变化。这些结果表明，慢性锂治疗可能会导致人体[³H]-丙咪嗪结合产生敏感性降低，并且这种离子的作用可能与锂在治疗情感障碍方面已确立的作用密切相关。
