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原发性硬化性胆管炎(PSC)伴或不伴炎症性肠病(IBD)的肝移植-欧洲器官移植学会(ESOT)共识声明。

Liver Transplantation for Primary Sclerosing Cholangitis (PSC) With or Without Inflammatory Bowel Disease (IBD)-A European Society of Organ Transplantation (ESOT) Consensus Statement.

机构信息

Centre for Autoimmune Liver Diseases, Department of Medicina and Surgery, University of Milano-Bicocca, Milan, Italy.

European Reference Network on Hepatological Diseases (ERN RARE-LIVER), IRCCS San Gerardo dei Tintori, Monza, Italy.

出版信息

Transpl Int. 2023 Sep 29;36:11729. doi: 10.3389/ti.2023.11729. eCollection 2023.

Abstract

Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of inflammatory bowel disease (IBD) and a lead indication for liver transplantation (LT) in the western world. In this article, we present a Consensus Statement on LT practice, developed by a dedicated Guidelines' Taskforce of the European Society of Organ Transplantation (ESOT). The overarching goal is to provide practical guidance on commonly debated topics, including indications and timing of LT, management of bile duct stenosis in patients on the transplant waiting list, technical aspects of transplantation, immunosuppressive strategies post-transplant, timing and extension of intestinal resection and futility criteria for re-transplantation.

摘要

原发性硬化性胆管炎(PSC)是炎症性肠病(IBD)的经典肝胆表现,也是西方世界进行肝移植(LT)的主要指征。在本文中,我们提出了一份由欧洲器官移植学会(ESOT)专门的指南工作组制定的关于 LT 实践的共识声明。总体目标是就常见争议话题提供实用指导,包括 LT 的适应证和时机、移植等待名单上患者胆管狭窄的管理、移植技术方面、移植后免疫抑制策略、肠道切除术的时机和范围以及再次移植的无效标准。

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