Ramakrishnan Pavithra, Amin Khalid, Gaertner Wolfgang, Aby Elizabeth S
Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Department of Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
Case Rep Transplant. 2024 Nov 12;2024:4699128. doi: 10.1155/crit/4699128. eCollection 2024.
De novo or viral reactivation cancers are a major cause of morbidity and mortality in the solid organ transplant (SOT) population. Primary sclerosing cholangitis (PSC) is an aggressive disease which can lead to cholestatic liver damage and cirrhosis. PSC often cooccurs with inflammatory bowel disease (IBD). Here, we describe the case of a 28-year-old male with PSC along with poorly controlled IBD who underwent a liver transplant and developed colonic Kaposi sarcoma (KS). Our case highlights the importance of adequate pretransplant screening for endemic viruses, high clinical suspicion for KS in the setting of difficult-to-control colitis, and early multidisciplinary involvement.
新发或病毒再激活引发的癌症是实体器官移植（SOT）人群发病和死亡的主要原因。原发性硬化性胆管炎（PSC）是一种侵袭性疾病，可导致胆汁淤积性肝损伤和肝硬化。PSC常与炎症性肠病（IBD）同时出现。在此，我们描述了一名28岁男性的病例，该患者患有PSC以及控制不佳的IBD，接受了肝移植并发生了结肠卡波西肉瘤（KS）。我们的病例强调了移植前对地方性病毒进行充分筛查的重要性、在难以控制的结肠炎背景下对KS保持高度临床怀疑以及早期多学科参与的重要性。
