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用于淋巴管静脉吻合手术的超声造影淋巴绘图:我们的操作方法。

Lymphatic Mapping with Contrast-enhanced Ultrasound for Lymphaticovenous Anastomosis Surgery: How We Do It.

作者信息

Jang Samuel, Bustos Samyd S, Chen Austin D, Zheng Eugene E, Hesley Gina K, Brinkman Nathan J, Carter Jill S, Tran Nho V, Fahradyan Vahe, Lee Christine U

机构信息

From the Department of Radiology, Mayo Clinic, Rochester, Minn.

Department of Plastic Surgery, Mayo Clinic, Rochester, Minn.

出版信息

Plast Reconstr Surg Glob Open. 2023 Oct 12;11(10):e5328. doi: 10.1097/GOX.0000000000005328. eCollection 2023 Oct.


DOI:10.1097/GOX.0000000000005328
PMID:37842077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10569760/
Abstract

Lymphaticovenous anastomosis (LVA) surgery is an effective surgery for the treatment of lymphedema in the extremities. Indocyanine green lymphography is the reference standard for visualizing lymphatics for LVA surgery, but it has several limitations; most notably, superficial dermal congestion can mask deeper lymphatic vessels. To overcome the limitations, we add contrast-enhanced ultrasound (CEUS) lymphography. We have previously reported that CEUS lymphography can identify lymphatic vessels for LVA surgery that indocyanine green lymphography does not. Here, we describe how we perform CEUS lymphography, including workflow, technique, and documentation. Before informed consent, the patient must be screened for possible adverse reactions to microbubbles. The procedure involves multiple intradermal injections of the microbubble agent at various sites along the extremity. After each injection, imaging for microbubble uptake by lymphatic vessels is performed using an ultrasound scanner with contrast-specific software. We use sulfur hexafluoride lipid-type A microspheres (Lumason/SonoVue; Bracco Suisse SA), but we are investigating the performance of other Food & Drug Administration-approved microbubble agents for CEUS lymphography. Having a systematic approach to marking the skin can mitigate the hindrance of marking over ultrasound coupling gel. Another benefit of CEUS lymphography is the rapid identification of neighboring veins compatible in size and location for anastomosis. We hold regular scheduled multidisciplinary meetings for coordination of care, discussion of outcomes, quality assurance, and ongoing innovation.

摘要

淋巴静脉吻合术(LVA)是治疗肢体淋巴水肿的一种有效手术。吲哚菁绿淋巴管造影是LVA手术中可视化淋巴管的参考标准,但它有一些局限性;最明显的是,浅表真皮充血会掩盖更深层的淋巴管。为了克服这些局限性,我们增加了对比增强超声(CEUS)淋巴管造影。我们之前曾报道,CEUS淋巴管造影可以识别出吲哚菁绿淋巴管造影无法识别的用于LVA手术的淋巴管。在此,我们描述我们如何进行CEUS淋巴管造影,包括工作流程、技术和记录。在获得知情同意之前,必须对患者进行微泡可能不良反应的筛查。该操作包括在肢体的不同部位进行多次皮内注射微泡剂。每次注射后,使用带有对比剂专用软件的超声扫描仪对淋巴管摄取微泡的情况进行成像。我们使用六氟化硫脂质型A微球(Lumason/SonoVue;Bracco Suisse SA),但我们正在研究其他美国食品药品监督管理局批准的用于CEUS淋巴管造影的微泡剂的性能。采用系统的皮肤标记方法可以减轻标记对超声耦合凝胶的阻碍。CEUS淋巴管造影的另一个好处是能快速识别出在大小和位置上适合吻合的相邻静脉。我们定期召开多学科会议,以协调护理、讨论结果、保证质量并持续创新。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d499/10569760/baf2308a27af/gox-11-e5328-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d499/10569760/531ce671ebd0/gox-11-e5328-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d499/10569760/baf2308a27af/gox-11-e5328-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d499/10569760/531ce671ebd0/gox-11-e5328-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d499/10569760/baf2308a27af/gox-11-e5328-g002.jpg

相似文献

[1]
Lymphatic Mapping with Contrast-enhanced Ultrasound for Lymphaticovenous Anastomosis Surgery: How We Do It.

Plast Reconstr Surg Glob Open. 2023-10-12

[2]
Lymphatic Mapping Using US Microbubbles before Lymphaticovenous Anastomosis Surgery for Lymphedema.

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[3]
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Plast Reconstr Surg Glob Open. 2024-7-17

[4]
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[5]
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[6]
An Allergic Reaction in Contrast-enhanced Ultrasound Lymphography for Lymphovenous Bypass Surgery.

Plast Reconstr Surg Glob Open. 2024-6-17

[7]
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[8]
The Significance of Contrast-Enhanced Ultrasound in the Application of Lymphaticovenous Anastomosis.

Curr Med Imaging. 2023-11-29

[9]
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[10]
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引用本文的文献

[1]
Application of percutaneous lymphatic contrast-enhanced ultrasound in lymphovenous anastomosis microsurgery.

PLoS One. 2025-8-22

[2]
Comparative Evaluation of Contrast-enhanced Ultrasound and Indocyanine Green Lymphography for Lymphatic Mapping: A Retrospective Study.

Plast Reconstr Surg Glob Open. 2025-8-1

[3]
Establishing a Standard Method for Screening Lymphatic Ultrasound in Lymphedema Patients.

Plast Reconstr Surg Glob Open. 2025-6-25

[4]
Randomized Feasibility Study Evaluating Multiple FDA-approved Microbubbles for CEUS Lymphography.

Plast Reconstr Surg Glob Open. 2024-7-17

[5]
Lymphatic Mapping for LVA with Noncontrast Lymphatic Ultrasound: How We Do It.

Plast Reconstr Surg Glob Open. 2024-4-15

本文引用的文献

[1]
Contrast-enhanced ultrasound: a new tool for imaging the superficial lymphatic vessels of the upper limb.

Eur Radiol Exp. 2022-4-12

[2]
Lymphatic Mapping Using US Microbubbles before Lymphaticovenous Anastomosis Surgery for Lymphedema.

Radiology. 2022-7

[3]
Preoperative localization of sentinel lymph nodes using percutaneous contrast-enhanced ultrasonography in patients with breast cancer.

Gland Surg. 2022-2

[4]
New Developments in Imaging for Sentinel Lymph Node Biopsy in Early-Stage Oral Cavity Squamous Cell Carcinoma.

Cancers (Basel). 2020-10-20

[5]
Two Non-gadolinium-based, Innovative Approaches to Preoperative Lymphangiography.

Plast Reconstr Surg Glob Open. 2020-4-22

[6]
Lymphaticovenous Anastomosis for Lower Extremity Lymphedema: A Systematic Review.

Indian J Plast Surg. 2020-3

[7]
Effect of Lymphaticovenous Anastomosis in Breast Cancer-Related Lymphedema: A Review of the Literature.

Lymphat Res Biol. 2018-10

[8]
Preoperative sentinel lymph node identification, biopsy and localisation using contrast enhanced ultrasound (CEUS) in patients with breast cancer: a systematic review and meta-analysis.

Clin Radiol. 2017-11

[9]
Update on the safety and efficacy of commercial ultrasound contrast agents in cardiac applications.

Echo Res Pract. 2015-6-1

[10]
Preoperative sentinel node identification with ultrasound using microbubbles in patients with breast cancer.

AJR Am J Roentgenol. 2011-2

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