Jang Samuel, Bustos Samyd S, Chen Austin D, Zheng Eugene E, Hesley Gina K, Brinkman Nathan J, Carter Jill S, Tran Nho V, Fahradyan Vahe, Lee Christine U
From the Department of Radiology, Mayo Clinic, Rochester, Minn.
Department of Plastic Surgery, Mayo Clinic, Rochester, Minn.
Plast Reconstr Surg Glob Open. 2023 Oct 12;11(10):e5328. doi: 10.1097/GOX.0000000000005328. eCollection 2023 Oct.
Lymphaticovenous anastomosis (LVA) surgery is an effective surgery for the treatment of lymphedema in the extremities. Indocyanine green lymphography is the reference standard for visualizing lymphatics for LVA surgery, but it has several limitations; most notably, superficial dermal congestion can mask deeper lymphatic vessels. To overcome the limitations, we add contrast-enhanced ultrasound (CEUS) lymphography. We have previously reported that CEUS lymphography can identify lymphatic vessels for LVA surgery that indocyanine green lymphography does not. Here, we describe how we perform CEUS lymphography, including workflow, technique, and documentation. Before informed consent, the patient must be screened for possible adverse reactions to microbubbles. The procedure involves multiple intradermal injections of the microbubble agent at various sites along the extremity. After each injection, imaging for microbubble uptake by lymphatic vessels is performed using an ultrasound scanner with contrast-specific software. We use sulfur hexafluoride lipid-type A microspheres (Lumason/SonoVue; Bracco Suisse SA), but we are investigating the performance of other Food & Drug Administration-approved microbubble agents for CEUS lymphography. Having a systematic approach to marking the skin can mitigate the hindrance of marking over ultrasound coupling gel. Another benefit of CEUS lymphography is the rapid identification of neighboring veins compatible in size and location for anastomosis. We hold regular scheduled multidisciplinary meetings for coordination of care, discussion of outcomes, quality assurance, and ongoing innovation.
淋巴静脉吻合术(LVA)是治疗肢体淋巴水肿的一种有效手术。吲哚菁绿淋巴管造影是LVA手术中可视化淋巴管的参考标准,但它有一些局限性;最明显的是,浅表真皮充血会掩盖更深层的淋巴管。为了克服这些局限性,我们增加了对比增强超声(CEUS)淋巴管造影。我们之前曾报道,CEUS淋巴管造影可以识别出吲哚菁绿淋巴管造影无法识别的用于LVA手术的淋巴管。在此,我们描述我们如何进行CEUS淋巴管造影,包括工作流程、技术和记录。在获得知情同意之前,必须对患者进行微泡可能不良反应的筛查。该操作包括在肢体的不同部位进行多次皮内注射微泡剂。每次注射后,使用带有对比剂专用软件的超声扫描仪对淋巴管摄取微泡的情况进行成像。我们使用六氟化硫脂质型A微球(Lumason/SonoVue;Bracco Suisse SA),但我们正在研究其他美国食品药品监督管理局批准的用于CEUS淋巴管造影的微泡剂的性能。采用系统的皮肤标记方法可以减轻标记对超声耦合凝胶的阻碍。CEUS淋巴管造影的另一个好处是能快速识别出在大小和位置上适合吻合的相邻静脉。我们定期召开多学科会议,以协调护理、讨论结果、保证质量并持续创新。
Plast Reconstr Surg Glob Open. 2023-10-12
Plast Reconstr Surg Glob Open. 2024-7-17
J Plast Reconstr Aesthet Surg. 2019-3-2
Plast Reconstr Surg Glob Open. 2024-6-17
Curr Med Imaging. 2023-11-29
Plast Reconstr Surg Glob Open. 2025-8-1
Plast Reconstr Surg Glob Open. 2025-6-25
Plast Reconstr Surg Glob Open. 2024-7-17
Plast Reconstr Surg Glob Open. 2024-4-15
Plast Reconstr Surg Glob Open. 2020-4-22
Indian J Plast Surg. 2020-3
AJR Am J Roentgenol. 2011-2