Jain Divya Prakash, Dinakar Yirivinti Hayagreeva, Kumar Hitesh, Jain Rupshee, Jain Vikas
Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru 570015, India.
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru 570015, India.
Cancer Drug Resist. 2023 Jul 28;6(3):481-498. doi: 10.20517/cdr.2023.17. eCollection 2023.
Prostate cancer is the second most prominent form of cancer in men and confers the highest mortality after lung cancer. The term "extracellular vesicles" refers to minute endosomal-derived membrane microvesicles and it was demonstrated that extracellular vesicles affect the environment in which tumors originate. Extracellular vesicles' involvement is also established in the development of drug resistance, angiogenesis, stemness, and radioresistance in various cancers including prostate cancer. Extracellular vesicles influence the general environment, processes, and growth of prostate cancer and can be a potential area that offers a significant lead in prostate cancer therapy. In this review, we have elaborated on the multifaceted role of extracellular vesicles in various processes involved in the development of prostate cancer, and their multitude of applications in the diagnosis and treatment of prostate cancer through the encapsulation of various bioactives.
前列腺癌是男性中第二常见的癌症形式，其死亡率仅次于肺癌。“细胞外囊泡”一词指的是微小的内体来源的膜微泡，并且已证明细胞外囊泡会影响肿瘤发生的环境。细胞外囊泡在包括前列腺癌在内的各种癌症的耐药性、血管生成、干性和放射抗性的发展中也有参与。细胞外囊泡会影响前列腺癌的整体环境、进程和生长，并且可能成为在前列腺癌治疗中提供重大突破的潜在领域。在这篇综述中，我们阐述了细胞外囊泡在前列腺癌发展所涉及的各种过程中的多方面作用，以及它们通过封装各种生物活性物质在前列腺癌诊断和治疗中的众多应用。
