Ramirez J A, Emmett M, White M G, Fathi N, Santa Ana C A, Morawski S G, Fordtran J S
Kidney Int. 1986 Nov;30(5):753-9. doi: 10.1038/ki.1986.252.
Absorption of dietary phosphorus plays a critical role in the development of metabolic bone diseases in patients with chronic renal failure. However, phosphorus absorption is difficult to quantitate in dialysis patients because the dialysis treatments complicate metabolic balance studies. Utilizing a recently developed technique which permits measurement of net absorption of dietary constituents after a single meal, we measured phosphorus absorption in dialysis patients. The following observations were made: A.) Following a meal containing approximately 300 mg phosphorus, mean phosphorus absorption in five hemodialysis patients (with severe vitamin D deficiency) was only slightly less than in matched controls (186 +/- 35 vs. 242 +/- 30). B.) After dialysis patients were treated with 1,25(OH)2-D3, phosphorus absorption increased from 186 +/- 35 to 272 +/- 16 mg (P less than 0.025). C.) The effect of three aluminum containing antacids on phosphorus absorption was studied; each slightly reduced the absorption of phosphorus compared to placebo (P less than 0.01), but there was no significant difference between them. D.) Aluminum hydroxide and calcium carbonate each reduced dietary phosphorus absorption to approximately the same extent. Calcium carbonate ingestion was associated with sharply increased calcium absorption. The absorption of dietary phosphorus is influenced only modestly by 1,25(OH)2-D3 and is inhibited to an equal but only modest degree by various aluminum antacids and by calcium carbonate.
膳食磷的吸收在慢性肾衰竭患者代谢性骨病的发展中起着关键作用。然而，由于透析治疗使代谢平衡研究变得复杂，因此在透析患者中难以对磷的吸收进行定量。利用一种最近开发的技术，该技术允许在单次进食后测量膳食成分的净吸收，我们测量了透析患者的磷吸收。得出以下观察结果：A. 进食含约300毫克磷的一餐之后，五名血液透析患者（严重维生素D缺乏）的平均磷吸收仅略低于匹配的对照组（186±35对242±30）。B. 透析患者接受1,25(OH)₂-D₃治疗后，磷吸收从186±35增加到272±16毫克（P<0.025）。C. 研究了三种含铝抗酸剂对磷吸收的影响；与安慰剂相比，每种抗酸剂均使磷吸收略有降低（P<0.01），但它们之间无显著差异。D. 氢氧化铝和碳酸钙对膳食磷吸收的降低程度大致相同。摄入碳酸钙与钙吸收急剧增加有关。膳食磷的吸收仅受到1,25(OH)₂-D₃的适度影响，并受到各种铝抗酸剂和碳酸钙同等但仅适度程度的抑制。
