Spencer H, Kramer L, Norris C, Osis D
Am J Clin Nutr. 1982 Jul;36(1):32-40. doi: 10.1093/ajcn/36.1.32.
The effect of small doses of four commercially available aluminum-containing antacids on calcium and phosphorus metabolism was investigated in adult males in 20 studies. During the use of these doses of antacids, urinary and fecal calcium increased significantly during a low calcium intake averaging 252 mg/day, and the calcium balances became distinctly more negative. There was a reversal of the normal pattern of phosphorus excretions, namely, the fecal phosphorus was high and the urinary phosphorus was low. During a normal calcium intake of 800 mg/day, these doses of antacids did not result in significant changes of the calcium excretions or balance. Despite the decrease in net intestinal absorption of calcium, the average 47Ca absorption remained unchanged, irrespective of the type and dose of antacid used. In three patients who received large therapeutic doses of antacids, 240 to 450 ml/day, the changes of calcium and phosphorus metabolism were intensified.
在20项研究中，对成年男性研究了四种市售含铝抗酸剂小剂量对钙和磷代谢的影响。在使用这些剂量抗酸剂期间，平均每日钙摄入量为252毫克的低钙摄入情况下，尿钙和粪钙显著增加，钙平衡明显变得更负。磷排泄的正常模式发生了逆转，即粪磷高而尿磷低。在每日钙摄入量正常为800毫克时，这些剂量的抗酸剂未导致钙排泄或平衡的显著变化。尽管肠道钙净吸收减少，但无论使用何种类型和剂量的抗酸剂，平均47Ca吸收仍保持不变。在三名接受大治疗剂量（每天240至450毫升）抗酸剂的患者中，钙和磷代谢的变化加剧。
