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Relatlimab, an Immune Checkpoint Inhibitor that Blocks LAG-3, the Latest Drug to be Added to the Arsenal of Systemic Therapies for Melanoma: What Does a Surgical Oncologist Need to Know?

作者信息

van Akkooi Alexander C J

机构信息

Melanoma Institute Australia, Sydney, NSW, Australia.

Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

出版信息

Ann Surg Oncol. 2024 Jan;31(1):1-3. doi: 10.1245/s10434-023-14416-0. Epub 2023 Oct 16.

DOI:10.1245/s10434-023-14416-0
PMID:37843663
Abstract
摘要

相似文献

1
Relatlimab, an Immune Checkpoint Inhibitor that Blocks LAG-3, the Latest Drug to be Added to the Arsenal of Systemic Therapies for Melanoma: What Does a Surgical Oncologist Need to Know?瑞帕利单抗,一种阻断淋巴细胞活化基因-3(LAG-3)的免疫检查点抑制剂,是黑色素瘤全身治疗武器库中最新添加的药物:外科肿瘤学家需要了解什么?
Ann Surg Oncol. 2024 Jan;31(1):1-3. doi: 10.1245/s10434-023-14416-0. Epub 2023 Oct 16.
2
Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma.Relatlimab 和 Nivolumab 对比 Nivolumab 用于未经治疗的晚期黑色素瘤。
N Engl J Med. 2022 Jan 6;386(1):24-34. doi: 10.1056/NEJMoa2109970.
3
Nivolumab/Relatlimab: A Novel Addition to Immune Checkpoint Inhibitor Therapy in Unresectable or Metastatic Melanoma.纳武利尤单抗/雷莫芦单抗:不可切除或转移性黑色素瘤免疫检查点抑制剂治疗的新选择。
Ann Pharmacother. 2023 Jun;57(6):738-745. doi: 10.1177/10600280221131396. Epub 2022 Oct 21.
4
Nivolumab and relatlimab for the treatment of melanoma.纳武利尤单抗和瑞派利单抗用于治疗黑色素瘤。
Drugs Today (Barc). 2023 Feb;59(2):91-104. doi: 10.1358/dot.2023.59.2.3509756.
5
Educational Review: Clinical Application of Immune Checkpoint Blockade for the Treatment of Melanoma.教育评论:免疫检查点阻断在黑色素瘤治疗中的临床应用。
Ann Surg Oncol. 2024 Mar;31(3):1865-1879. doi: 10.1245/s10434-023-14587-w. Epub 2023 Nov 21.
6
Immune Checkpoint Therapies for Melanoma.免疫检查点疗法治疗黑色素瘤。
Hematol Oncol Clin North Am. 2021 Feb;35(1):99-109. doi: 10.1016/j.hoc.2020.08.013. Epub 2020 Oct 26.
7
Advancement of anti-LAG-3 in cancer therapy.抗LAG-3在癌症治疗中的进展。
FASEB J. 2023 Nov;37(11):e23236. doi: 10.1096/fj.202301018R.
8
Relatlimab: a novel drug targeting immune checkpoint LAG-3 in melanoma therapy.瑞帕利单抗:一种用于黑色素瘤治疗的靶向免疫检查点LAG-3的新型药物。
Front Pharmacol. 2024 Jan 10;14:1349081. doi: 10.3389/fphar.2023.1349081. eCollection 2023.
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Neoadjuvant relatlimab and nivolumab in resectable melanoma.新辅助雷利度胺和纳武利尤单抗治疗可切除黑色素瘤。
Nature. 2022 Nov;611(7934):155-160. doi: 10.1038/s41586-022-05368-8. Epub 2022 Oct 26.
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Double Trouble: Immunotherapy Doublets in Melanoma-Approved and Novel Combinations to Optimize Treatment in Advanced Melanoma.双重打击:黑色素瘤获批的免疫治疗双药联合以及新型组合方案,以优化晚期黑色素瘤的治疗。
Am Soc Clin Oncol Educ Book. 2022 Apr;42:1-22. doi: 10.1200/EDBK_351123.

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The Expression Patterns of Immune Checkpoint Molecules in Colorectal Cancer: An Analysis Based on Microsatellite Status.结直肠癌中免疫检查点分子的表达模式:基于微卫星状态的分析
Biomedicines. 2024 Mar 28;12(4):752. doi: 10.3390/biomedicines12040752.
2
Relatlimab: a novel drug targeting immune checkpoint LAG-3 in melanoma therapy.瑞帕利单抗:一种用于黑色素瘤治疗的靶向免疫检查点LAG-3的新型药物。
Front Pharmacol. 2024 Jan 10;14:1349081. doi: 10.3389/fphar.2023.1349081. eCollection 2023.
3
Overview of current melanoma therapies.当前黑色素瘤疗法概述。

本文引用的文献

1
The introduction of LAG-3 checkpoint blockade in melanoma: immunotherapy landscape beyond PD-1 and CTLA-4 inhibition.黑色素瘤中LAG-3检查点阻断疗法的引入:超越PD-1和CTLA-4抑制的免疫治疗格局
Ther Adv Med Oncol. 2023 Jul 17;15:17588359231186027. doi: 10.1177/17588359231186027. eCollection 2023.
2
Health-related quality of life with nivolumab plus relatlimab versus nivolumab monotherapy in patients with previously untreated unresectable or metastatic melanoma: RELATIVITY-047 trial.纳武利尤单抗联合瑞派利单抗对比纳武利尤单抗单药治疗既往未治疗的不可切除或转移性黑色素瘤患者的健康相关生活质量:RELATIVITY-047试验
Eur J Cancer. 2023 Jul;187:164-173. doi: 10.1016/j.ejca.2023.03.014. Epub 2023 Mar 22.
3
Pigment Cell Melanoma Res. 2024 Sep;37(5):562-568. doi: 10.1111/pcmr.13154. Epub 2023 Dec 8.
Neoadjuvant-Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma.
新辅助-辅助或仅辅助派姆单抗治疗晚期黑色素瘤。
N Engl J Med. 2023 Mar 2;388(9):813-823. doi: 10.1056/NEJMoa2211437.
4
Nivolumab and Relatlimab in Patients With Advanced Melanoma That Had Progressed on Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy: Results From the Phase I/IIa RELATIVITY-020 Trial.纳武利尤单抗和雷莫芦单抗治疗抗程序性死亡-1/程序性死亡配体 1 治疗后进展的晚期黑色素瘤患者:RELATIVITY-020 试验的 I/IIa 期结果。
J Clin Oncol. 2023 May 20;41(15):2724-2735. doi: 10.1200/JCO.22.02072. Epub 2023 Feb 13.
5
Survival update of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma in the OpACIN and OpACIN-neo trials.奥卡替尼和奥卡替尼-新试验中新辅助伊匹单抗加纳武单抗治疗宏观 III 期黑色素瘤的生存更新。
Ann Oncol. 2023 Apr;34(4):420-430. doi: 10.1016/j.annonc.2023.01.004. Epub 2023 Jan 18.
6
Neoadjuvant relatlimab and nivolumab in resectable melanoma.新辅助雷利度胺和纳武利尤单抗治疗可切除黑色素瘤。
Nature. 2022 Nov;611(7934):155-160. doi: 10.1038/s41586-022-05368-8. Epub 2022 Oct 26.
7
Management of toxicities from immunotherapy: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.免疫疗法毒性的管理:ESMO诊断、治疗及随访临床实践指南
Ann Oncol. 2022 Dec;33(12):1217-1238. doi: 10.1016/j.annonc.2022.10.001. Epub 2022 Oct 18.
8
Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial.新辅助伊匹单抗和纳武利尤单抗治疗高危 III 期黑色素瘤后的个体化反应导向手术和辅助治疗:PRADO 试验。
Nat Med. 2022 Jun;28(6):1178-1188. doi: 10.1038/s41591-022-01851-x. Epub 2022 Jun 5.
9
Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial.帕博利珠单抗对比安慰剂作为完全切除的IIB期或IIC期黑色素瘤辅助治疗(KEYNOTE-716):一项随机、双盲、3期试验
Lancet. 2022 Apr 30;399(10336):1718-1729. doi: 10.1016/S0140-6736(22)00562-1. Epub 2022 Apr 1.
10
Neoadjuvant Systemic Therapy (NAST) in Patients with Melanoma: Surgical Considerations by the International Neoadjuvant Melanoma Consortium (INMC).新辅助全身治疗(NAST)在黑色素瘤患者中的应用:国际新辅助黑色素瘤联盟(INMC)的手术考虑。
Ann Surg Oncol. 2022 Jun;29(6):3694-3708. doi: 10.1245/s10434-021-11236-y. Epub 2022 Jan 28.