Faculty of Psychology, Universidad Antonio Nariño, Cali, Colombia.
Faculty of Psychology, Universidad Cooperativa de Colombia-Campus Cali.
AIDS Educ Prev. 2023 Oct;35(5):362-375. doi: 10.1521/aeap.2023.35.5.362.
Prevalence of human immunodeficiency virus (HIV) is higher in transgender populations. Pre-exposure prophylaxis (PrEP) intervention is successful in reducing HIV acquisition. We aimed to investigate the adherence to oral PrEP by HIV-negative transgender women (TW). We followed the and the PRISMA Statement. We searched in WoS, OVID, Scopus, MEDLINE, and the Cochrane Central Register of Controlled Trials databases. Participation and adherence to the intervention were low for TW compared to cisgender men who have sex with men (cMSM), and it was measured mostly by self-report (72.7%) or tenofovir-diphosphate/emtricitabine triphosphate dried blood spot (45.5%). Awareness should increase and the effect of oral PrEP on gender-affirming hormone therapy should be explained to TW at the beginning of the trials. One limitation is that our sample size was dominated by two Thai studies with TW sex workers. Future studies should evaluate adherence to new PrEP modalities.
艾滋病毒（HIV）在跨性别群体中的流行率更高。暴露前预防（PrEP）干预措施在降低 HIV 感染方面取得了成功。我们旨在研究 HIV 阴性跨性别女性（TW）对口服 PrEP 的依从性。我们遵循了 和 PRISMA 声明。我们在 WoS、OVID、Scopus、MEDLINE 和 Cochrane 中央对照试验注册库数据库中进行了搜索。与顺性别男男性行为者（cMSM）相比，TW 对干预措施的参与度和依从性较低，且主要通过自我报告（72.7%）或替诺福韦二吡呋酯/恩曲他滨三磷酸干血斑（45.5%）来衡量。在试验开始时，应提高 TW 对口服 PrEP 的认识，并向其解释口服 PrEP 对性别肯定激素治疗的影响。一个限制是，我们的样本量主要由两项针对 TW 性工作者的泰国研究组成。未来的研究应评估新的 PrEP 模式的依从性。
