Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo, Japan.
Department of Chemical Engineering, Kyoto University, Kyoto, Japan.
PLoS Comput Biol. 2023 Oct 16;19(10):e1011533. doi: 10.1371/journal.pcbi.1011533. eCollection 2023 Oct.
Epidemics of infectious diseases posing a serious risk to human health have occurred throughout history. During recent epidemics there has been much debate about policy, including how and when to impose restrictions on behaviour. Policymakers must balance a complex spectrum of objectives, suggesting a need for quantitative tools. Whether health services might be 'overwhelmed' has emerged as a key consideration. Here we show how costly interventions, such as taxes or subsidies on behaviour, can be used to exactly align individuals' decision making with government preferences even when these are not aligned. In order to achieve this, we develop a nested optimisation algorithm of both the government intervention strategy and the resulting equilibrium behaviour of individuals. We focus on a situation in which the capacity of the healthcare system to treat patients is limited and identify conditions under which the disease dynamics respect the capacity limit. We find an extremely sharp drop in peak infections at a critical maximum infection cost in the government's objective function. This is in marked contrast to the gradual reduction of infections if individuals make decisions without government intervention. We find optimal interventions vary less strongly in time when interventions are costly to the government and that the critical cost of the policy switch depends on how costly interventions are.
传染病的流行对人类健康构成了严重威胁,在历史上时有发生。在最近的几次疫情中,人们对政策进行了广泛的讨论,包括如何以及何时对行为施加限制。政策制定者必须在一系列复杂的目标之间取得平衡,这表明需要定量工具。卫生服务是否可能“不堪重负”已成为一个关键考虑因素。在这里,我们展示了昂贵的干预措施(例如对行为征税或补贴)如何能够精确地使个人的决策与政府偏好保持一致,即使这些偏好不一致。为了实现这一目标,我们开发了一种嵌套优化算法,同时优化政府干预策略和个人的均衡行为。我们专注于医疗保健系统治疗患者能力有限的情况,并确定了疾病动态符合能力限制的条件。我们发现,在政府目标函数中,感染成本达到临界最大值时,感染峰值会急剧下降。这与如果个人在没有政府干预的情况下做出决策,感染人数逐渐减少形成鲜明对比。我们发现,当干预措施对政府来说代价高昂时,最优干预措施在时间上的变化不那么剧烈,而且政策转变的关键成本取决于干预措施的代价。