The Eighth Affiliated Hospital, Sun Yat-sen University, No. 3025, Shennan Middle Rd, Futian District, 518033 Shenzhen, China.
Department of Internal Medicine, AMRI Hospital, Kolkata, India.
Biomed Pharmacother. 2023 Dec;168:115693. doi: 10.1016/j.biopha.2023.115693. Epub 2023 Oct 14.
Vascular calcification (VC), an actively regulated process, has been recognized as an independent and strong predictor of cardiovascular disease (CVD) and mortality worldwide. Diet has been shown to have a major role in the progression of VC. Oxidative stress (OS), a common pro-calcification factor, is closely related to VC, and evidence strongly suggests that dietary antioxidants directly prevent VC. Herein, we provided an overview of OS and its key role in VC and underlined the mechanisms of harmful effects of OS on VC. Furthermore, we introduced dietary antioxidants, and discussed about surrounding the challenges of dietary antioxidants in VC management. This review will benefit future research about the effects of dietary antioxidants on cardiovascular health.
血管钙化（VC）是一个受到主动调控的过程，它已被认为是全球心血管疾病（CVD）和死亡率的一个独立且强有力的预测因素。饮食已被证明在 VC 的进展中起着重要作用。氧化应激（OS）是一个常见的促钙化因子，与 VC 密切相关，有证据强烈表明，膳食抗氧化剂可以直接预防 VC。本文概述了 OS 及其在 VC 中的关键作用，并强调了 OS 对 VC 的有害影响的机制。此外，我们介绍了膳食抗氧化剂，并讨论了 VC 管理中膳食抗氧化剂所面临的挑战。这篇综述将有助于未来关于膳食抗氧化剂对心血管健康影响的研究。
