Department of Ophthalmology, Hospital Clínico San Carlos de Madrid, Madrid, Spain.
Universidad Complutense de Madrid, Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Madrid, Spain.
Eur J Ophthalmol. 2024 May;34(3):678-682. doi: 10.1177/11206721231207116. Epub 2023 Oct 16.
To analyze the efficacy of liposomal ozonated oil (Ozonest®) treatment, in patients with blepharitis or blepharoconjunctivitis, in improving the signs and symptoms of the pathology.
Exploratory, open-label, prospective, single-arm, pre-post comparative pilot study in usual clinical practice, in 20 patients with blepharitis/blepharoconjunctivitis, receiving treatment with liposomal ozonated oil, one drop in each eye, 4 times a day, for 28 days. Main purpose was to assess whether there was a clinically improvement in the blepharitis specific BLISS questionnaire score. Changes in the 12-item OSDI, in eyelid signs of blepharitis assessed by the physicians were also evaluated among other tests, and there was also a subjective evaluation of the treatment by patients.
The BLISS score significantly improved from 16.4 before treatment to 11.8 after treatment (< 0.05). The OSDI score was also significantly improved from 27.5 before treatment to 20.5 after treatment (< 0.05). All tests conducted before and after treatment showed significant improvement (< 0.05), except for NIBUT. The treatment received a score of 7 out of 10 by the patients. There were no adverse events in any patient.
Liposomal ozonated oil treatment showed good efficacy in improving the signs and symptoms of blepharitis/blepharoconjunctivitis, satisfaction of patients, and good safety and tolerability.
分析脂质体臭氧油（Ozonest®）治疗睑缘炎或睑结膜炎患者的疗效，以改善该疾病的体征和症状。
在常规临床实践中进行探索性、开放标签、前瞻性、单臂、前后比较的初步研究，纳入 20 例患有睑缘炎/睑结膜炎的患者，接受脂质体臭氧油治疗，每天 4 次，每次滴入每只眼 1 滴，共 28 天。主要目的是评估 BLISS 睑缘炎特定问卷评分是否有临床改善。还评估了 12 项 OSDI、医生评估的睑缘炎的眼睑体征变化等其他测试，以及患者对治疗的主观评价。
BLISS 评分从治疗前的 16.4 显著改善至治疗后的 11.8（<0.05）。OSDI 评分也从治疗前的 27.5 显著改善至治疗后的 20.5（<0.05）。所有测试均显示治疗前后均有显著改善（<0.05），除了 NIBUT。患者对治疗的评价得分为 7 分（满分 10 分）。没有任何患者出现不良反应。
脂质体臭氧油治疗在改善睑缘炎/睑结膜炎的体征和症状、患者满意度以及良好的安全性和耐受性方面显示出良好的疗效。
