Neiberger R E, Passmore J C
Circ Shock. 1978;5(4):339-45.
Intrarenal blood flow distribution during the stages of endotoxemia in the dog was studied using radioactive inert gas washout. Intrarenal blood flow distribution was determined: a) at control, b) 0.5 hours following injection of a lethal dose (3 mg/kg) of E coli endotoxin, and c) 2.5 hours following endotoxin injection in control dogs and dogs pretreated with 4 mg/kg of phenoxybenzamine. One-half hour following endotoxin injection, components I and II of the inert gas washout curve fused. Presumably this fusion occurred because component I flow decreased to a level indistinguishable from that of component II. Following 2.5 hours of endotoxemia, components I and II were both present. Pretreatment with phenoxybenzamine completely prevented the fusion of components I and II, although the mean arterial blood pressure was substantially lower than in dogs not pretreated with phenoxybenzamine. After 2.5 hours of endotoxemia, four of the five phenoxybenzamine pretreated dogs still had two clearly defined washout components. It is concluded that the renal cortical vascular response in endotoxemia is similar to that reported following hemorrhage and that the alpha-adrenergic nervous system plays a major role in decreasing renal cortical blood flow.
采用放射性惰性气体洗脱法研究了犬内毒素血症各阶段的肾内血流分布情况。测定了肾内血流分布：a）对照时；b）注射致死剂量（3mg/kg）大肠杆菌内毒素后0.5小时；c）在对照犬以及用4mg/kg酚苄明预处理的犬注射内毒素后2.5小时。注射内毒素后半小时，惰性气体洗脱曲线的I和II成分融合。据推测，这种融合的发生是因为I成分血流降至与II成分血流难以区分的水平。内毒素血症持续2.5小时后，I和II成分均存在。酚苄明预处理完全阻止了I和II成分的融合，尽管平均动脉血压显著低于未用酚苄明预处理的犬。内毒素血症持续2.5小时后，五只经酚苄明预处理的犬中有四只仍有两个清晰可辨的洗脱成分。得出的结论是，内毒素血症时肾皮质血管反应与出血后报道的情况相似，且α-肾上腺素能神经系统在减少肾皮质血流中起主要作用。
