Image Reconstruction Using Deep Learning for Near-Infrared Optical Tomography: Generalization Assessment.

Time is one of the most critical factors in preventing brain lesions due to hypoxic ischemia in preterm infants. Since early detection of low oxygenation is vital and the time window for therapy is narrow, near-infrared optical tomography (NIROT) must be able to process the high-dimensional data provided by today's advanced systems in the shortest possible time. Deep learning approaches are attractive because they can exploit such high information density while reducing inference time. The aim of this study was to evaluate the performance of a hybrid convolutional neural network, designed for NIROT image reconstruction and trained on synthetic data. Generalization capability was assessed using measurements on phantoms of a surface topology more divergent than the range of variation in the geometries of the in-silico data, with unseen, non-spherical inclusion shapes, and with source and detector arrangements different from those used for data generation. Substantial gains in speed, localization accuracy, and high image quality were achieved even under the highly varied measurement conditions.