Interdisciplinary Program in Senior Human Ecology, Changwon National University, Changwon, Korea.
Department of Food and Nutrition, Changwon National University, Changwon, Korea.
Endocrinol Metab (Seoul). 2023 Oct;38(5):482-492. doi: 10.3803/EnM.2023.1776. Epub 2023 Oct 17.
This review explores the potential benefits of taurine in ameliorating the metabolic disorders of obesity and type 2 diabetes (T2D), highlighting the factors that bridge these associations. Relevant articles and studies were reviewed to conduct a comprehensive analysis of the relationship between obesity and the development of T2D and the effect of taurine on those conditions. The loss of normal β-cell function and development of T2D are associated with obesity-derived insulin resistance. The occurrence of diabetes has been linked to the low bioavailability of taurine, which plays critical roles in normal β-cell function, anti-oxidation, and anti-inflammation. The relationships among obesity, insulin resistance, β-cell dysfunction, and T2D are complex and intertwined. Taurine may play a role in ameliorating these metabolic disorders through different pathways, but further research is needed to fully understand its effects and potential as a therapeutic intervention.
本综述探讨了牛磺酸在改善肥胖和 2 型糖尿病(T2D)代谢紊乱方面的潜在益处,强调了连接这些关联的因素。回顾了相关的文章和研究,以对肥胖与 T2D 发展之间的关系以及牛磺酸对这些疾病的影响进行全面分析。正常β细胞功能的丧失和 T2D 的发展与肥胖引起的胰岛素抵抗有关。糖尿病的发生与牛磺酸的生物利用度降低有关,牛磺酸在正常β细胞功能、抗氧化和抗炎中起着关键作用。肥胖、胰岛素抵抗、β细胞功能障碍和 T2D 之间的关系复杂且相互交织。牛磺酸可能通过不同途径在改善这些代谢紊乱方面发挥作用,但需要进一步研究以充分了解其作为治疗干预的效果和潜力。