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牛磺酸对肥胖相关性糖尿病的影响:其作用的潜在机制。

The Impact of Taurine on Obesity-Induced Diabetes Mellitus: Mechanisms Underlying Its Effect.

机构信息

Interdisciplinary Program in Senior Human Ecology, Changwon National University, Changwon, Korea.

Department of Food and Nutrition, Changwon National University, Changwon, Korea.

出版信息

Endocrinol Metab (Seoul). 2023 Oct;38(5):482-492. doi: 10.3803/EnM.2023.1776. Epub 2023 Oct 17.

Abstract

This review explores the potential benefits of taurine in ameliorating the metabolic disorders of obesity and type 2 diabetes (T2D), highlighting the factors that bridge these associations. Relevant articles and studies were reviewed to conduct a comprehensive analysis of the relationship between obesity and the development of T2D and the effect of taurine on those conditions. The loss of normal β-cell function and development of T2D are associated with obesity-derived insulin resistance. The occurrence of diabetes has been linked to the low bioavailability of taurine, which plays critical roles in normal β-cell function, anti-oxidation, and anti-inflammation. The relationships among obesity, insulin resistance, β-cell dysfunction, and T2D are complex and intertwined. Taurine may play a role in ameliorating these metabolic disorders through different pathways, but further research is needed to fully understand its effects and potential as a therapeutic intervention.

摘要

本综述探讨了牛磺酸在改善肥胖和 2 型糖尿病(T2D)代谢紊乱方面的潜在益处,强调了连接这些关联的因素。回顾了相关的文章和研究,以对肥胖与 T2D 发展之间的关系以及牛磺酸对这些疾病的影响进行全面分析。正常β细胞功能的丧失和 T2D 的发展与肥胖引起的胰岛素抵抗有关。糖尿病的发生与牛磺酸的生物利用度降低有关,牛磺酸在正常β细胞功能、抗氧化和抗炎中起着关键作用。肥胖、胰岛素抵抗、β细胞功能障碍和 T2D 之间的关系复杂且相互交织。牛磺酸可能通过不同途径在改善这些代谢紊乱方面发挥作用,但需要进一步研究以充分了解其作为治疗干预的效果和潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d07/10613769/f63db298033a/enm-2023-1776f1.jpg

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