Department of Perinatology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey.
Department of Perinatology, Etlik City Hospital, Ankara, Turkey.
Rev Bras Ginecol Obstet. 2023 Sep;45(9):e511-e516. doi: 10.1055/s-0043-1775847. Epub 2023 Oct 16.
The aim of the present study is to compare the cavum septum pellucidi (CSP) z-score in euploid and aneuploid fetuses and to investigate the performance of the CSP width/length and CSP width/biparietal diameter (BPD) ratios as a diagnostic marker in aneuploidy.
A total of 54 patients, 20 aneuploid and 35 euploid fetuses, between 18 and 37 weeks of gestation, were included in this retrospective study. The CSP width z-score was compared between the two groups. Receiver operating characteristic (ROC) curves were calculated for the CSP width/length and CSP width/BPD ratios to predict aneuploidy.
The median CSP width was 4.8 mm (range, 1.8 to 8.5 mm) in the euploid group, and 5.4 mm (range 3.1 to 8.4 mm) in the aneuploid group. Cavum septum pellucidi width z-score, CSP width/length ratio, and CSP width/BPD ratio were significantly higher in fetuses with aneuploidy than in fetuses with normal karyotype ( = 0.001; = 0.013; = 0.028). In the ROC analysis, the CSP width/length ratio had the optimal cutoff value of 0.59, with 72.0% sensitivity and 58.0% specificity, and for the CSP width/BPD ratio, the cutoff value was 0.081 with 83.0% sensitivity and 61.0% specificity for detection of aneuploidy.
CSP width z-score was found to be increased in aneuploid fetuses. The CSP width /BPD ratio can be used as a new marker for predicting aneuploidy.
本研究旨在比较正常核型和非整倍体胎儿的透明隔腔（CSP）Z 评分，并探讨 CSP 宽度/长度比和 CSP 宽度/双顶径（BPD）比作为非整倍体诊断标志物的性能。
本回顾性研究纳入了 54 例 18 至 37 周妊娠的患者，其中 20 例为非整倍体，35 例为正常核型。比较了两组之间的 CSP 宽度 Z 评分。计算了 CSP 宽度/长度比和 CSP 宽度/BPD 比的受试者工作特征（ROC）曲线，以预测非整倍体。
正常核型组的 CSP 宽度中位数为 4.8mm（范围 1.8 至 8.5mm），非整倍体组为 5.4mm（范围 3.1 至 8.4mm）。CSP 宽度 Z 评分、CSP 宽度/长度比和 CSP 宽度/BPD 比在非整倍体胎儿中明显高于正常核型胎儿（=0.001；=0.013；=0.028）。在 ROC 分析中，CSP 宽度/长度比的最佳截断值为 0.59，灵敏度为 72.0%，特异性为 58.0%，而对于 CSP 宽度/BPD 比，截断值为 0.081，灵敏度为 83.0%，特异性为 61.0%，用于检测非整倍体。
非整倍体胎儿的 CSP 宽度 Z 评分升高。CSP 宽度/BPD 比可用作预测非整倍体的新标志物。
