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胃癌的热灌注腹腔内化疗:一例长期生存的临床病例

Hyperthermic Intraperitoneal Chemotherapy in Gastric Cancer: A Clinical Case Involving Long-Term Survival.

作者信息

Duarte Mendes Ana, Vicente Rodrigo, Fernandes Manuel, Silva Michelle

机构信息

Oncology, Hospital Professor Doutor Fernando Fonseca, Amadora, PRT.

General Surgery, Instituto Português de Oncologia do Porto, Porto, PRT.

出版信息

Cureus. 2023 Sep 15;15(9):e45302. doi: 10.7759/cureus.45302. eCollection 2023 Sep.

DOI:10.7759/cureus.45302
PMID:37846258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10576960/
Abstract

Peritoneal metastasis is the most common pattern of synchronous and metachronous dissemination in gastric cancer (GC) and is associated with a poor prognosis. Even though systemic chemotherapy is the standard of care, the optimal therapeutic approach to peritoneal disease in this setting is yet to be defined. We present a case of a 26-year-old female diagnosed with locally advanced GC who developed peritoneal carcinomatosis (PC). The patient underwent cytoreductive surgery (CRS) along with hyperthermic intraperitoneal chemotherapy (HIPEC) with complete remission. She remained disease-free after six years, presenting with peritoneal recurrence 70 months after the procedure. This report describes a rare case of long-term survival following a controversial therapeutic approach.

摘要

腹膜转移是胃癌(GC)同步和异时播散最常见的模式,且与预后不良相关。尽管全身化疗是标准治疗方法,但针对这种情况下腹膜疾病的最佳治疗方法尚未确定。我们报告一例26岁女性,被诊断为局部晚期胃癌并发生腹膜癌病(PC)。该患者接受了减瘤手术(CRS)以及腹腔内热灌注化疗(HIPEC),实现了完全缓解。六年内她一直无病生存,术后70个月出现腹膜复发。本报告描述了一例采用有争议的治疗方法后长期生存的罕见病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d82/10576960/96614a1d77bb/cureus-0015-00000045302-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d82/10576960/6bd415b9e872/cureus-0015-00000045302-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d82/10576960/bf57c5137db7/cureus-0015-00000045302-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d82/10576960/96614a1d77bb/cureus-0015-00000045302-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d82/10576960/6bd415b9e872/cureus-0015-00000045302-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d82/10576960/bf57c5137db7/cureus-0015-00000045302-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d82/10576960/96614a1d77bb/cureus-0015-00000045302-i03.jpg

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结直肠和阑尾腹膜转移的细胞减灭术和腹腔热灌注化疗(HIPEC)-香港经验和文献复习。
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