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新生大鼠单次接受烯丙雌醇或己烯雌酚治疗对成年大鼠肝脏微粒体酶活性的影响。

Influence of single neonatal treatment with allylestrenol or diethylstilbestrol on microsomal enzyme activity of rat liver in adulthood.

作者信息

Csaba G, Szeberényi S, Dobozy O

出版信息

Med Biol. 1986;64(4):197-200.

PMID:3784633
Abstract

A single neonatal treatment of rats with a steroid (allylestrenol or diethylstilbestrol) did not alter the later activity of the hepatic microsomal (cytochrome P-450) enzyme system, but inhibited the inducer action of another steroid (testosterone) administered at the age of six weeks. This suggests that a hormonal imprinting-like mechanism also operates in the case of enzymes.

摘要

用一种类固醇(烯丙雌醇或己烯雌酚)对新生大鼠进行单次处理,并未改变其肝脏微粒体(细胞色素P - 450)酶系统的后期活性,但抑制了六周龄时给予的另一种类固醇(睾酮)的诱导作用。这表明,在酶的情况下,一种类似激素印记的机制也在起作用。

相似文献

1
Influence of single neonatal treatment with allylestrenol or diethylstilbestrol on microsomal enzyme activity of rat liver in adulthood.新生大鼠单次接受烯丙雌醇或己烯雌酚治疗对成年大鼠肝脏微粒体酶活性的影响。
Med Biol. 1986;64(4):197-200.
2
Influence of neonatal steroid (diethylstilbestrol, allylestrenol) treatment on the sexual behaviour of the adult rat.新生期类固醇(己烯雌酚、烯丙雌醇)处理对成年大鼠性行为的影响。
Med Biol. 1986;64(4):193-5.
3
Role of neonatal androgen in the development of hepatic microsomal drug-metabolizing enzymes.新生儿雄激素在肝脏微粒体药物代谢酶发育中的作用。
J Pharmacol Exp Ther. 1975 May;193(2):621-30.
4
Hormonal imprinting and damages caused by fetal steroid treatment. Influence of fetal treatment with pregnancy-protecting steroids (allylestrenol, diethylstilbestrol) on the effect of gonadotropin administered to cockerels perinatally and at the age of six weeks.
Acta Physiol Hung. 1988;71(1):5-18.
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Effect of embryonic and/or neonatal diethylstilbestrol and allylestrenol treatment on postnatal development of the chick testis.胚胎期和/或新生期己烯雌酚及烯丙雌醇处理对雏鸡睾丸出生后发育的影响
Acta Morphol Hung. 1987;35(1-2):19-30.
6
Administration of benzpyrene and allylestrenol in fetal or neonatal periods of life: does it make difference in the microsomal activity?
Acta Physiol Hung. 1994;82(4):331-7.
7
[Hepatic microsomal monoxygenase inhibition by nabam in the rat (author's transl)].代森锌对大鼠肝微粒体单加氧酶的抑制作用(作者译)
Toxicol Eur Res. 1981 Nov;3(6):285-91.
8
Lack of in vitro and in vitro effects of fenbendazole on phase I and phase II biotransformation enzymes in rats, mice and chickens.芬苯达唑对大鼠、小鼠和鸡体内I相和II相生物转化酶的体内外作用缺乏。
Vet Hum Toxicol. 1991 Dec;33(6):548-51.
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Hormonal imprinting of the microsomal enzyme system in adults. Microsomal activity change in response to estrogen (DES, AE) treatment during liver regeneration.成人微粒体酶系统的激素印记。肝脏再生过程中微粒体活性对雌激素(己烯雌酚、炔雌醇)治疗的反应变化。
Horm Metab Res. 1987 Oct;19(10):493-6. doi: 10.1055/s-2007-1011861.
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Effect of alpha-pinene on the mixed function microsomal oxidase system in the rat.α-蒎烯对大鼠混合功能微粒体氧化酶系统的影响。
Acta Med Acad Sci Hung. 1976;33(4):379-85.

引用本文的文献

1
Receptor ontogeny and hormonal imprinting.受体个体发生与激素印记。
Experientia. 1986 Jul 15;42(7):750-9. doi: 10.1007/BF01941521.