新生大鼠单次接受烯丙雌醇或己烯雌酚治疗对成年大鼠肝脏微粒体酶活性的影响。
Influence of single neonatal treatment with allylestrenol or diethylstilbestrol on microsomal enzyme activity of rat liver in adulthood.
作者信息
Csaba G, Szeberényi S, Dobozy O
出版信息
Med Biol. 1986;64(4):197-200.
PMID:3784633
Abstract
A single neonatal treatment of rats with a steroid (allylestrenol or diethylstilbestrol) did not alter the later activity of the hepatic microsomal (cytochrome P-450) enzyme system, but inhibited the inducer action of another steroid (testosterone) administered at the age of six weeks. This suggests that a hormonal imprinting-like mechanism also operates in the case of enzymes.
摘要
用一种类固醇（烯丙雌醇或己烯雌酚）对新生大鼠进行单次处理，并未改变其肝脏微粒体（细胞色素P - 450）酶系统的后期活性，但抑制了六周龄时给予的另一种类固醇（睾酮）的诱导作用。这表明，在酶的情况下，一种类似激素印记的机制也在起作用。
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