Csaba G, Szeberényi S Z, Dobozy O
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Horm Metab Res. 1987 Oct;19(10):493-6. doi: 10.1055/s-2007-1011861.
Estrogen (diethylstilbestrol-DES or allylestrenol-AE) treatment applied to rats of both sexes during liver regeneration following subtotal hepatectomy had a long lasting influence on the inducibility by phenobarbital of the hepatic microsomal enzyme system of the females. The enzyme activities of the DES-treated females differed hardly from the baseline two weeks after treatment, but increased almost two-fold over control on induction with phenobarbital 5 and 7 weeks later. The AE-treated females showed a smaller although yet significant, enzyme activity increase only at 7 weeks. The influence of estrogens was negligible, and inhibitory rather than stimulatory, in the males. It appears that, in appropriate conditions, enzyme imprinting can also be induced in adult organisms, since, in all probability, availability for imprinting depends not so much on the age of the organism, as on the developmental state of the target cell.
在大鼠进行次全肝切除术后肝脏再生期间，对雌雄大鼠应用雌激素（己烯雌酚-DES或烯丙雌醇-AE）治疗，对雌性大鼠肝脏微粒体酶系统经苯巴比妥诱导的诱导能力产生了持久影响。经DES治疗的雌性大鼠的酶活性在治疗后两周与基线水平几乎没有差异，但在5周和7周后用苯巴比妥诱导时，其酶活性比对照组增加了近两倍。经AE治疗的雌性大鼠仅在7周时酶活性有较小但仍显著的增加。雌激素对雄性大鼠的影响可忽略不计，且是抑制而非刺激作用。似乎在适当条件下，酶印记也可在成年生物体中诱导产生，因为很可能，可用于印记的条件与其说是取决于生物体的年龄，不如说是取决于靶细胞的发育状态。
