Li Hengyu, Zhou Yu, Guo Xiaoxia, Zhang Qiwei, Ding Xiaoyi
Department of Interventional Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin Er Road, Shanghai, 200025, China.
J Interv Med. 2023 Aug 7;6(3):107-110. doi: 10.1016/j.jimed.2023.07.005. eCollection 2023 Aug.
Recently, interventional ablation techniques have gained prominence in tumor treatment guidelines and complement traditional approaches, such as surgery, chemotherapy, and radiotherapy. Conventional ablation techniques, such as microwave, radiofrequency, and cryoablation, have been used; however, they have certain limitations, including the risk of damaging surrounding normal tissues and the heat sink effect caused by tumor blood flow. Irreversible electroporation (IRE), an ablation technology independent of thermal energy, is a promising alternative. Clinical studies have demonstrated IRE's efficacy in treating tumors, such as pancreatic and liver tumors. Recent research has shown that IRE can elicit specific anti-tumor immune responses in the body. IRE also plays a crucial role in eliminating residual tumor cells postoperatively and preventing tumor recurrence.
近年来，介入消融技术在肿瘤治疗指南中备受瞩目，并成为传统治疗方法（如手术、化疗和放疗）的补充。传统的消融技术，如微波、射频和冷冻消融，已被广泛应用；然而，它们存在一定的局限性，包括损伤周围正常组织的风险以及肿瘤血流引起的热沉效应。不可逆电穿孔（IRE）作为一种独立于热能的消融技术，是一种很有前景的替代方法。临床研究已证实IRE在治疗肿瘤（如胰腺和肝脏肿瘤）方面的有效性。最近的研究表明，IRE可在体内引发特定的抗肿瘤免疫反应。IRE在术后清除残留肿瘤细胞和预防肿瘤复发方面也起着关键作用。
