Atypical Clinical presentation of a patient with Monkeypox.

Presentation The Monkeypox virus is spreading in the European continent. A 36-year-old Irish man presented with a cellulitis lesion on the nose, spreading to the cheeks and upper lip. Atypical clinical features of the evolving outbreak are posing a community and healthcare risk to its management. Diagnosis Real-time PCR assay of the lesion swab revealed Monkeypox virus. The biochemical and hematological blood indices were normal, except for C-Reactive Protein, which was higher than normal. Treatment The patient was put on 750 mg intravenous Acyclovir, 15mg/kg twice a day of Vancomycin and 2g/day Ceftriaxone infusion. Discussion Cellulitis lesions are an atypical clinical feature of Monkeypox virus infection. Its management, using antibiotics and antiviral drugs, treated the infection and confined the spread of the virus around the patient's nose.