Hajjo Rima, Abusara Osama H, Sabbah Dima A, Bardaweel Sanaa K
Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, P.O. Box 130, Amman, 11733, Jordan.
Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
BMC Infect Dis. 2025 Apr 15;25(1):529. doi: 10.1186/s12879-025-10899-2.
Mpox, previously known as monkeypox, is a zoonotic viral disease caused by the Mpox virus (MPXV), a member of the Orthopoxvirus genus. This disease is of significant concern due to its zoonotic transmission, which can be challenging to control, its ability to spread easily from person to person, the potential for severe symptoms or even fatality, and its history of frequent global outbreaks. Despite the growing threat, there is still limited research on the pathophysiology of the disease and available disease-modifying treatments. To address this gap, the latest developments in Mpox epidemiology, viral variant detection, and advanced diagnostic tools for accurate MPXV detection have been reviewed. Ongoing preventive measures, including vaccination strategies, have also been examined. Additionally, the genomic and proteomic characteristics of MPXV have been explored, and network and pathway enrichment analyses have been performed to identify potential therapeutic targets. The findings presented in this manuscript suggest the potential for novel disease-modifying treatments. Moreover, emerging technologies, such as artificial intelligence and "big data," are playing a crucial role in advancing disease management and enhancing prevention strategies. This review emphasizes the evolving understanding of Mpox and MPXV variants and underscores the importance of continued research and public health initiatives to combat the disease and prevent future global outbreaks.
猴痘，以前称为猴痘，是一种由猴痘病毒（MPXV）引起的人畜共患病毒性疾病，猴痘病毒属于正痘病毒属。由于其人畜共患传播难以控制、易于在人与人之间传播、可能出现严重症状甚至死亡以及全球频繁爆发的历史，这种疾病备受关注。尽管威胁不断增加，但关于该疾病病理生理学和可用的疾病改善治疗方法的研究仍然有限。为填补这一空白，本文综述了猴痘流行病学、病毒变异检测以及准确检测MPXV的先进诊断工具的最新进展。还研究了正在进行的预防措施，包括疫苗接种策略。此外，还探索了MPXV的基因组和蛋白质组特征，并进行了网络和通路富集分析以确定潜在的治疗靶点。本手稿中的研究结果表明了新型疾病改善治疗方法的潜力。此外，人工智能和“大数据”等新兴技术在推进疾病管理和加强预防策略方面发挥着关键作用。这篇综述强调了对猴痘和MPXV变异体不断演变的认识，并强调了持续研究和公共卫生举措对于抗击该疾病和预防未来全球爆发的重要性。
