Kim H S, Iyengar S, Wood P L
Life Sci. 1986 Nov 24;39(21):2033-6. doi: 10.1016/0024-3205(86)90327-9.
The actions of parenteral morphine were examined with regard to dopamine metabolism in the mesocortical dopaminergic pathways of the rat. The effects of morphine on dopamine metabolism in the prefrontal, cingulate, pyriform and entorhinal cortices were compared with the actions of morphine on the metabolism of dopamine in the striatum and olfactory tubercle. In all tissues, except the entorhinal cortex, morphine significantly elevated the dopamine metabolites dihydroxphenylacetic acid and homovanillic acid. These data, along with previous studies of various pharmacological agents, clearly indicate that the mesocortical dopaminergic projections possess unique opioid and non-opioid regulatory inputs.
研究了胃肠外给予吗啡对大鼠中皮质多巴胺能通路中多巴胺代谢的影响。将吗啡对前额叶、扣带回、梨状和内嗅皮质中多巴胺代谢的作用，与吗啡对纹状体和嗅结节中多巴胺代谢的作用进行了比较。在除内嗅皮质外的所有组织中，吗啡均显著提高了多巴胺代谢产物二羟基苯乙酸和高香草酸的水平。这些数据，连同先前对各种药理制剂的研究，清楚地表明中皮质多巴胺能投射具有独特的阿片类和非阿片类调节输入。
