Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, China.
Cell Reprogram. 2023 Oct;25(5):183-186. doi: 10.1089/cell.2023.0100.
Reprogramming is traditionally defined as the fate conversion of a cell to a stage of increased developmental potential. In its broader meaning, the reprogramming term is also applied to all forms of cell fate conversion that do not follow a developmental trajectory. Reprogramming is now a well-established field of research that gained rapid progress upon the advent of induced pluripotency. In this perspective, I reflect on the reprogramming lessons of the past, in the contributions to other fields of research and on the potential transformative future use of reprogrammed cells and of its cell derivatives.
重编程通常被定义为细胞向发育潜能增加阶段的命运转变。在更广泛的意义上，重编程这个术语也适用于所有不符合发育轨迹的细胞命运转变形式。重编程是一个已经确立的研究领域，在诱导多能性出现后取得了快速进展。从这个角度出发，我反思了过去的重编程经验教训，以及这些经验教训在其他研究领域的贡献，以及重编程细胞及其细胞衍生物在未来可能具有的变革性用途。
