Department of Nursing, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
First Branch of Nephrology Department, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
BMJ Paediatr Open. 2023 Oct;7(1). doi: 10.1136/bmjpo-2023-002151.
Impaired physical function is relatively common in children/adolescents with chronic kidney disease (CKD), affecting not only patients' daily lives but also the efficiency of later treatment and rehabilitation. Exercise is a recognised intervention to improve physical function and quality of life in adult patients with CKD. However, implementing this strategy in paediatric/adolescent populations remains relatively limited. For exercise training to be widely delivered as part of paediatric public health policy, a better understanding of the physical function and the impact of exercise interventions in children/adolescents with CKD is needed.
A systematic review and meta-analysis will be conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to compare physical function in children/adolescents with CKD with healthy controls and the impact of exercise interventions on their outcomes. The systematic review will search the following databases: PubMed, Embase, Scopus and Web of Science. We will use the Risk Of Bias In Non-Randomised Studies-of Interventions and the second edition of the Cochrane Risk of Bias to assess the quality of the literature. Where feasible, we will conduct random effects meta-analyses where appropriate. If possible, we will conduct subgroup analyses to explore potential sources of heterogeneity.
Due to the nature of the protocol, ethical approval is not required. We will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to disseminate the study results through publication and conference presentations.
CRD42023416208.
慢性肾脏病（CKD）患儿/青少年的身体机能受损较为常见，这不仅影响患者的日常生活，还会影响后续治疗和康复的效率。运动是一种公认的干预措施，可以改善成人 CKD 患者的身体机能和生活质量。然而，在儿科/青少年人群中实施这一策略仍然相对有限。为了使运动训练作为儿科公共卫生政策的一部分广泛实施，需要更好地了解 CKD 患儿/青少年的身体机能以及运动干预对其结果的影响。
本研究将遵循系统评价和荟萃分析的首选报告项目指南进行系统评价和荟萃分析，以比较 CKD 患儿/青少年的身体机能与健康对照组，并评估运动干预对其结果的影响。系统评价将搜索以下数据库：PubMed、Embase、Scopus 和 Web of Science。我们将使用非随机干预研究的偏倚风险和 Cochrane 偏倚的第二版来评估文献的质量。在可行的情况下，我们将进行随机效应荟萃分析。如有可能，我们将进行亚组分析以探索潜在的异质性来源。
由于方案的性质，不需要伦理批准。我们将遵循系统评价和荟萃分析的首选报告项目指南，通过发表和会议报告来传播研究结果。
PROSPERO 注册号：CRD42023416208。
