Fairman C M, Owens O L, Kendall K L, Steele J, Schumpp A R, Latella C, Jones M T, Marcotte L, Dawson J M, Peddle-McIntyre C M J, McDonnell K K
Department of Exercise Science, University of South Carolina, Columbia, USA.
College of Social Work, University of South Carolina, Columbia, USA.
Pilot Feasibility Stud. 2023 Oct 17;9(1):177. doi: 10.1186/s40814-023-01405-z.
Individuals with non-small cell lung cancer (NSCLC) are burdened by long-lasting symptoms (e.g., dyspnea and fatigue) post-treatment. These symptoms often reduce physical activity levels and increase the risk of functional decline. Though we have previously proposed cluster-set resistance training to mitigate symptom burden in lung cancer, there is currently no data on the feasibility or acceptability of this mode of exercise in cancer. Therefore, the purpose of this study was to investigate the feasibility and acceptability of a hybrid-delivery home-based cluster-set resistance training program in individuals with NSCLC stages I-III (i.e., early stage).
This study aimed to recruit individuals with NSCLC stages I-III post-treatment to participate in 8 weeks of home-based resistance training, 3 days per week. The program included supervised sessions in the participants' homes and virtual supervision via videoconferencing. The primary outcome measure of feasibility was evaluated through recruitment, retention, and intervention fidelity (i.e., proportion of exercise completed, relative to what was prescribed). Intervention acceptability (i.e., ease and quality of virtual delivery, level of difficulty, and home-based approach) was assessed using a 4-point Likert-type scale from "strongly disagree" to "strongly agree".
Fourteen participants were recruited over a 6-month period, with 11 completing the intervention (2 withdrew due to unrelated illness, 1 withdrew due to requiring active treatment), yielding a retention rate of 79%. Characteristics of the participants who completed the intervention (n = 11) were as follows: mean age: 71 ± 10 years, mean BMI: 29.1 ± 6.5, and average time since diagnosis was 62 ± 51 months. Of completers, 27% were male, and 36% were Black; 10 were stage I (91%), and one was stage II (9%). Mean session attendance was 86.4 ± 9.5%. Mean intervention fidelity was 83.1 ± 13.1%. With regard to acceptability, > 90% of participants positively rated all aspects of the intervention delivery. No adverse events related to exercise were recorded.
The hybrid delivery of a home-based resistance exercise program for individuals previously treated for early-stage NSCLC was found to be safe and feasible. Adaptations to the program for future interventions are required, particularly surrounding resistance exercise programming, and intervention delivery with home visits.
ClinicalTrials.gov: NCT05014035 . Registered January 20, 2021.
非小细胞肺癌（NSCLC）患者在治疗后长期受症状（如呼吸困难和疲劳）困扰。这些症状常降低身体活动水平，增加功能衰退风险。尽管我们之前提出成组抗阻训练以减轻肺癌患者的症状负担，但目前尚无关于这种运动方式在癌症患者中的可行性或可接受性的数据。因此，本研究的目的是调查基于家庭的混合式成组抗阻训练计划在I - III期（即早期）NSCLC患者中的可行性和可接受性。
本研究旨在招募I - III期NSCLC治疗后的患者，参加为期8周、每周3天的家庭抗阻训练。该计划包括在参与者家中进行的现场指导课程以及通过视频会议进行的虚拟指导。可行性的主要结局指标通过招募、留存率和干预保真度（即完成的锻炼比例相对于规定内容）进行评估。干预可接受性（即虚拟授课的难易程度和质量、难度水平以及基于家庭的方式）使用从“强烈不同意”到“强烈同意”的4点李克特量表进行评估。
在6个月内招募了14名参与者，11人完成了干预（2人因无关疾病退出，1人因需要积极治疗退出），留存率为79%。完成干预的参与者（n = 11）的特征如下：平均年龄：71 ± 10岁，平均BMI：29.1 ± 6.5，自诊断以来的平均时间为62 ± 51个月。在完成者中，27%为男性，36%为黑人；10人为I期（91%），1人为II期（9%）。平均课程出勤率为86.4 ± 9.5%。平均干预保真度为83.1 ± 13.1%。关于可接受性，> 90%的参与者对干预实施的各个方面给予了积极评价。未记录到与运动相关的不良事件。
对于既往接受过早期NSCLC治疗的患者，基于家庭的抗阻运动计划的混合式实施被发现是安全可行的。未来干预需要对该计划进行调整，特别是围绕抗阻运动方案以及家访的干预实施。
ClinicalTrials.gov：NCT05014035。2021年1月20日注册。
