Fairman Ciaran M
Exercise Oncology Lab, Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States.
Front Sports Act Living. 2024 Dec 5;6:1418640. doi: 10.3389/fspor.2024.1418640. eCollection 2024.
Resistance exercise (RE) has been demonstrated to result in a myriad of benefits for individuals treated for cancer, including improvements in muscle mass, strength, physical function, and quality of life. Though this has resulted in the development of recommendations for RE in cancer management from various international governing bodies, there is also increasing recognition of the need to improve the design of RE interventions in oncology. The design and execution of RE trials are notoriously complex, attempting to account for numerous cancer/treatment related symptoms/side effects. Further, the design of exercise trials in oncology also present numerous logistical challenges, particularly those that are scaled for effectiveness, where multi-site trials with numerous exercise facilities are almost a necessity. As such, this review paper highlights these considerations, and takes evidence from relevant areas (RE trials/recommendations in oncology, older adults, and other clinical populations), and provide a practical framework for consideration in the design and delivery of RE trials. Ultimately, the purpose of this framework is to provide suggestions for researchers on how to design/conduct RE trials for individuals with cancer, rather than synthesizing evidence for guidelines/recommendations on the optimal RE dose/program.
抗阻运动（RE）已被证明对癌症患者有诸多益处，包括增加肌肉量、增强力量、改善身体功能和提高生活质量。尽管这促使各个国际管理机构针对癌症管理中的抗阻运动制定了相关建议，但人们也越来越认识到有必要改进肿瘤学中抗阻运动干预措施的设计。抗阻运动试验的设计和实施极其复杂，需要考虑众多与癌症/治疗相关的症状/副作用。此外，肿瘤学运动试验的设计还面临诸多后勤挑战，尤其是那些为提高有效性而扩大规模的试验，在这种情况下，几乎有必要开展涉及众多运动设施的多中心试验。因此，这篇综述文章强调了这些考虑因素，并借鉴了相关领域（肿瘤学、老年人及其他临床人群中的抗阻运动试验/建议）的证据，为抗阻运动试验的设计和实施提供了一个实用的框架供参考。最终，该框架的目的是为研究人员提供有关如何为癌症患者设计/开展抗阻运动试验的建议，而不是为关于最佳抗阻运动剂量/方案的指南/建议综合证据。
