Magerstädt M, Gansow O A, Brechbiel M W, Colcher D, Baltzer L, Knop R H, Girton M E, Naegele M
Magn Reson Med. 1986 Oct;3(5):808-12. doi: 10.1002/mrm.1910030517.
Methods have been devised for obtaining gadolinium(III) complexes of the ligands NOTA (1,4,7-triazacyclononane-N,N',N''-triacetic acid), DOTA (1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid), TETA (1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid), and DTPA (diethylenetriaminepentaacetic acid) as solids for use as pharmaceuticals. Their effectiveness as in vitro and in vivo contrast agents for NMR imaging or T1,2 relaxation agents for spectroscopy has been investigated. The Gd(DOTA) complex was shown to be a more stable alternative to Gd(DTPA) by serum stability studies and measurement of stability constants. Images of tumors grown in athymic mice were obtained by NMR after injection of Gd(DOTA) and Gd(DTPA).
已设计出一些方法来获得配体NOTA（1,4,7-三氮杂环壬烷-N,N',N''-三乙酸）、DOTA（1,4,7,10-四氮杂环十二烷-N,N',N'',N'''-四乙酸）、TETA（1,4,8,11-四氮杂环十四烷-N,N',N'',N'''-四乙酸）和DTPA（二乙烯三胺五乙酸）的钆（III）配合物，作为固体用于制药。已对它们作为用于核磁共振成像的体外和体内造影剂或用于光谱学的T1,2弛豫剂的有效性进行了研究。通过血清稳定性研究和稳定性常数的测量表明，钆（DOTA）配合物是比钆（DTPA）更稳定的替代品。在注射钆（DOTA）和钆（DTPA）后，通过核磁共振获得了无胸腺小鼠体内生长肿瘤的图像。
