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Unleashing the Potential of 1,3-Diketone Analogues as Selective LH2 Inhibitors.释放1,3 - 二酮类似物作为选择性LH2抑制剂的潜力。
ACS Med Chem Lett. 2023 Sep 22;14(10):1396-1403. doi: 10.1021/acsmedchemlett.3c00305. eCollection 2023 Oct 12.
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Development of a High-Throughput Lysyl Hydroxylase (LH) Assay and Identification of Small-Molecule Inhibitors against LH2.高通量赖氨酰羟化酶（LH）测定法的建立及 LH2 小分子抑制剂的鉴定。
SLAS Discov. 2019 Apr;24(4):484-491. doi: 10.1177/2472555218817057. Epub 2018 Dec 27.
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Computational Investigation of a Series of Small Molecules as Potential Compounds for Lysyl Hydroxylase-2 (LH2) Inhibition.计算研究一系列小分子作为赖氨酸羟化酶-2（LH2）抑制剂的潜在化合物。
J Chem Inf Model. 2023 Feb 13;63(3):986-1001. doi: 10.1021/acs.jcim.2c01448. Epub 2023 Jan 30.
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Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space.赖氨酰羟化酶2由肿瘤细胞分泌，可修饰细胞外空间中的胶原蛋白。
J Biol Chem. 2016 Dec 9;291(50):25799-25808. doi: 10.1074/jbc.M116.759803. Epub 2016 Nov 1.
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Lack of collagen type specificity for lysyl hydroxylase isoforms.赖氨酰羟化酶同工型缺乏胶原类型特异性。
DNA Cell Biol. 2000 Feb;19(2):71-7. doi: 10.1089/104454900314582.
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Lysyl hydroxylase 2 mediated collagen post-translational modifications and functional outcomes.赖氨酰羟化酶 2 介导的胶原蛋白翻译后修饰及其功能结果。
Sci Rep. 2022 Aug 22;12(1):14256. doi: 10.1038/s41598-022-18165-0.
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FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch.FKBP65 依赖性肽基脯氨酰顺反异构酶活性增强赖氨酰羟化酶 2 驱动的胶原蛋白交联转换。
Sci Rep. 2017 Apr 5;7:46021. doi: 10.1038/srep46021.
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The lysyl hydroxylase isoforms are widely expressed during mouse embryogenesis, but obtain tissue- and cell-specific patterns in the adult.赖氨酰羟化酶同工型在小鼠胚胎发育过程中广泛表达，但在成年期呈现出组织和细胞特异性模式。
Matrix Biol. 2006 Oct;25(8):475-83. doi: 10.1016/j.matbio.2006.08.260. Epub 2006 Aug 18.
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Generation of bone-specific lysyl hydroxylase 2 knockout mice and their phenotypes.骨特异性赖氨酰羟化酶2基因敲除小鼠的产生及其表型。
Biochem Biophys Rep. 2024 Jul 19;39:101790. doi: 10.1016/j.bbrep.2024.101790. eCollection 2024 Sep.
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Decrease of lysyl hydroxylase 2 activity causes abnormal collagen molecular phenotypes, defective mineralization and compromised mechanical properties of bone.赖氨酰羟化酶 2 活性降低导致胶原分子表型异常、矿化缺陷和骨机械性能受损。
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Computational studies on the functional and structural impact of pathogenic mutations in enzymes.酶中致病突变对功能和结构影响的计算研究。
Protein Sci. 2025 Apr;34(4):e70081. doi: 10.1002/pro.70081.
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Targeting PLOD2 suppresses invasion and metastatic potential in radiorecurrent prostate cancer.靶向赖氨酰氧化酶样蛋白2可抑制放射性复发前列腺癌的侵袭和转移潜能。
BJC Rep. 2024;2(1):60. doi: 10.1038/s44276-024-00085-3. Epub 2024 Aug 21.
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The Versatility of Collagen in Pharmacology: Targeting Collagen, Targeting with Collagen.胶原蛋白在药理学中的多功能性：靶向胶原蛋白，用胶原蛋白靶向。
Int J Mol Sci. 2024 Jun 13;25(12):6523. doi: 10.3390/ijms25126523.
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Exploring Extracellular Matrix Crosslinking as a Therapeutic Approach to Fibrosis.探索细胞外基质交联作为一种治疗纤维化的方法。
Cells. 2024 Mar 2;13(5):438. doi: 10.3390/cells13050438.
本文引用的文献
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Computational Investigation of a Series of Small Molecules as Potential Compounds for Lysyl Hydroxylase-2 (LH2) Inhibition.计算研究一系列小分子作为赖氨酸羟化酶-2（LH2）抑制剂的潜在化合物。
J Chem Inf Model. 2023 Feb 13;63(3):986-1001. doi: 10.1021/acs.jcim.2c01448. Epub 2023 Jan 30.
2
PLOD2 high expression associates with immune infiltration and facilitates cancer progression in osteosarcoma.PLOD2高表达与免疫浸润相关，并促进骨肉瘤的癌症进展。
Front Oncol. 2022 Oct 5;12:980390. doi: 10.3389/fonc.2022.980390. eCollection 2022.
3
Berberine Attenuates Cell Motility Inhibiting Inflammation-Mediated Lysyl Hydroxylase-2 and Glycolysis.黄连素通过抑制炎症介导的赖氨酰羟化酶-2和糖酵解来减弱细胞运动性。
Front Pharmacol. 2022 Apr 26;13:856777. doi: 10.3389/fphar.2022.856777. eCollection 2022.
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Comparison of Solution Chemical Properties and Biological Activity of Ruthenium Complexes of Selected -Diketone, 8-Hydroxyquinoline and Pyrithione Ligands.特定β-二酮、8-羟基喹啉和吡啶硫酮配体的钌配合物的溶液化学性质与生物活性比较
Pharmaceuticals (Basel). 2021 May 27;14(6):518. doi: 10.3390/ph14060518.
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A collagen glucosyltransferase drives lung adenocarcinoma progression in mice.胶原葡萄糖基转移酶驱动小鼠肺腺癌的进展。
Commun Biol. 2021 Apr 19;4(1):482. doi: 10.1038/s42003-021-01982-w.
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FTO - A Common Genetic Basis for Obesity and Cancer.FTO——肥胖与癌症的共同遗传基础。
Front Genet. 2020 Nov 16;11:559138. doi: 10.3389/fgene.2020.559138. eCollection 2020.
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Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note.米诺地尔不能用于靶向幼鼠肺发育过程中的赖氨酰羟化酶：一个警示。
J Pharmacol Exp Ther. 2020 Dec;375(3):478-487. doi: 10.1124/jpet.120.000138. Epub 2020 Oct 5.
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Collagen cross-linking mediated by lysyl hydroxylase 2: an enzymatic battlefield to combat fibrosis.赖氨酰羟化酶 2 介导的胶原蛋白交联：抗击纤维化的酶学战场。
Essays Biochem. 2019 Sep 13;63(3):377-387. doi: 10.1042/EBC20180051.
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Solid State and Solution Study on the Formation of Inorganic Anion Complexes with a Series of Tetrazine-Based Ligands.基于一系列四嗪配体的无机阴离子配合物的形成的固态和溶液研究。
Molecules. 2019 Jun 16;24(12):2247. doi: 10.3390/molecules24122247.
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SiMPLOD, a Structure-Integrated Database of Collagen Lysyl Hydroxylase (LH/PLOD) Enzyme Variants.SiMPLOD，胶原赖氨酰羟化酶（LH/PLOD）酶变体的结构整合数据库。
J Bone Miner Res. 2019 Jul;34(7):1376-1382. doi: 10.1002/jbmr.3692. Epub 2019 Mar 12.
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