Lan Ning, Lu Ying, Zhang Yigan, Pu Shuangshuang, Xi Huaze, Nie Xin, Liu Jing, Yuan Wenzhen
The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
The First Hospital of Lanzhou University, Lanzhou, China.
Front Genet. 2020 Nov 16;11:559138. doi: 10.3389/fgene.2020.559138. eCollection 2020.
In recent years, the prevalence of obesity and cancer have been rising. Since this poses a serious threat to human health, the relationship between the two has attracted much attention. This study examined whether fat mass and obesity-associated () genes are linked, taking into account a Genome-wide Association Study (GWAS) that revealed multiple single nucleotide polymorphism sites (SNPs) of the gene, indicating an association between obesity and cancer in different populations. FTO proteins have been proved to participate in adipogenesis and tumorigenesis with post-transcriptional regulation of downstream molecular expression or through the target of the mammalian target protein rapamycin (mTOR). FTO inhibitors have also been found to share anti-obesity and anti-cancer effects . In this review, we comprehensively discuss the correlation between obesity and cancer by measuring gene polymorphism, as well as the molecular mechanism involved in these diseases, emphasizing FTO as the common genetic basis of obesity and cancer.
近年来，肥胖症和癌症的患病率一直在上升。由于这对人类健康构成严重威胁，两者之间的关系备受关注。本研究考虑到一项全基因组关联研究（GWAS）揭示了该基因的多个单核苷酸多态性位点（SNP），表明肥胖与不同人群的癌症之间存在关联，从而检验了脂肪量与肥胖相关（）基因是否有关联。FTO蛋白已被证明通过对下游分子表达的转录后调控或通过哺乳动物雷帕霉素靶蛋白（mTOR）靶点参与脂肪生成和肿瘤发生。还发现FTO抑制剂具有抗肥胖和抗癌作用。在本综述中，我们通过测量基因多态性全面讨论肥胖与癌症之间的相关性，以及这些疾病所涉及的分子机制，强调FTO作为肥胖和癌症的共同遗传基础。
