Patrick M. Woster Memorial Commentary.
作者信息
Rotella David P, Georg Gunda
机构信息
Department of Chemistry and Biochemistry, Montclair State University, Montclair, New Jersey 07043, United States.
Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.
出版信息
ACS Med Chem Lett. 2023 Oct 3;14(10):1305-1309. doi: 10.1021/acsmedchemlett.3c00382. eCollection 2023 Oct 12.
Abstract
摘要
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Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease.使用可逆性赖氨酸特异性去甲基化酶1（LSD1）抑制剂实现血红蛋白F的表观遗传重表达：镰状细胞病的潜在治疗方法
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Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes.多胺类似物对赖氨酸特异性去甲基化酶1的抑制作用导致异常沉默基因的重新表达。
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Alkyl-substituted polyaminohydroxamic acids: a novel class of targeted histone deacetylase inhibitors.烷基取代的聚氨基异羟肟酸：一类新型的靶向组蛋白脱乙酰酶抑制剂。
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