环缩酚酸肽的最新进展：用于药物研究的生物活性化合物
Recent advances on cyclodepsipeptides: biologically active compounds for drug research.
作者信息
Liu Si-Xuan, Ou-Yang Si-Yi, Lu Yong-Fu, Guo Chun-Lin, Dai Si-Yang, Li Chang, Yu Tian-Yi, Pei Yue-Hu
机构信息
Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, China.
Key Laboratory of Gut Microbiota and Pharmacogenomics of Heilongjiang Province, College of Pharmacy, Harbin Medical University, Harbin, China.
出版信息
Front Microbiol. 2023 Oct 2;14:1276928. doi: 10.3389/fmicb.2023.1276928. eCollection 2023.
Cyclodepsipeptides are a large family of peptide-related natural products consisting of hydroxy and amino acids linked by amide and ester bonds. A number of cyclodepsipeptides have been isolated and characterized from fungi and bacteria. Most of them showed antitumor, antifungal, antiviral, antimalarial, and antitrypanosomal properties. Herein, this review summarizes the recent literatures (2010-2022) on the progress of cyclodepsipeptides from fungi and bacteria except for those of marine origin, in order to enrich our knowledge about their structural features and biological sources.
环缩肽是一大类与肽相关的天然产物，由通过酰胺键和酯键连接的羟基酸和氨基酸组成。已经从真菌和细菌中分离并鉴定出许多环缩肽。它们中的大多数具有抗肿瘤、抗真菌、抗病毒、抗疟疾和抗锥虫的特性。在此，本综述总结了2010年至2022年期间除海洋来源外关于真菌和细菌中环缩肽进展的最新文献，以丰富我们对其结构特征和生物来源的认识。
Zotero 插件