三束枝菌素 A-D：来源于内生真菌的细胞毒环二肽。
Trichodestruxins A-D: Cytotoxic Cyclodepsipeptides from the Endophytic Fungus .
机构信息
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, People's Republic of China.
School of Pharmacy, Harbin Medical University, Harbin 150081, People's Republic of China.
出版信息
J Nat Prod. 2020 Dec 24;83(12):3635-3641. doi: 10.1021/acs.jnatprod.0c00808. Epub 2020 Dec 10.
Four new cyclodepsipeptides, trichodestruxins A-D (-), together with destruxin E2 chlorohydrin () and destruxin A2 (), were isolated from the plant endophytic fungus by a bioassay-guided fractionation method. Their planar structures were elucidated on the basis of 1D and 2D NMR and MS/MS spectroscopic analyses. The stereochemical configuration was established by application of the advanced Marfey's method, -based configuration analysis, Mosher's method, and chemical derivatizations. Trichodestruxin B contains hydroxy acid fragments of the THPA unit, while trichodestruxins A and C contain the β-methylproline moiety. All cyclodepsipeptides displayed cytotoxicity against HT-29, A549, and/or P388 cell lines with IC values of 0.7-19.1 μM.
四种新的环二肽，即 trichodestruxins A-D (-)，以及 destruxin E2 氯醇 () 和 destruxin A2 ()，从植物内生真菌 通过生物测定指导的分离方法分离得到。根据 1D 和 2D NMR 和 MS/MS 光谱分析，阐明了它们的平面结构。立体化学构型通过应用先进的 Marfey's 方法、基于的构型分析、Mosher's 方法和化学衍生化来确定。Trichodestruxin B 含有 THPA 单元的羟基酸片段，而 trichodestruxins A 和 C 含有β-甲基脯氨酸部分。所有环二肽都显示出对 HT-29、A549 和/或 P388 细胞系的细胞毒性，IC 值为 0.7-19.1 μM。
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