Feng Ting, Zhu Yunhao, Morris Richard, Kozloff Kenneth M, Wang Xueding
Department of Biomedical Engineering, University of Michigan Medical School, MI 48109, USA.
IF, LLC, WI 53589USA.
BME Front. 2020 Oct 30;2020:1081540. doi: 10.34133/2020/1081540. eCollection 2020.
. To study the feasibility of combined functional photoacoustic (PA) and quantitative ultrasound (US) for diagnosis of osteoporosis based on the detection of chemical and microarchitecture (BMA) information in calcaneus bone. . Clinically available X-ray or US technologies for the diagnosis of osteoporosis do not report important parameters such as chemical information and BMA. With unique advantages, including good sensitivity to molecular and metabolic properties, PA bone assessment techniques hold a great potential for clinical translation. . By performing multiwavelength PA measurements, the chemical information in the human calcaneus bone, including mineral, lipid, oxygenated-hemoglobin, and deoxygenated-hemoglobin, were assessed. In parallel, by performing PA spectrum analysis, the BMA as an important bone physical property was quantified. An unpaired -test and a two-way ANOVA test were conducted to compare the outcomes from the two subject groups. . Multiwavelength PA measurement is capable of assessing the relative contents of several chemical components in the trabecular bone , including both minerals and organic materials such as oxygenated-hemoglobin, deoxygenated-hemoglobin, and lipid, which are relevant to metabolic activities and bone health. In addition, PA measurements of BMA show good correlations ( up to 0.65) with DEXA. Both the chemical and microarchitectural measurements from PA techniques can differentiate the two subject groups. . The results from this initial clinical study suggest that PA techniques, by providing additional chemical and microarchitecture information relevant to bone health, may lead to accurate and early diagnosis, as well as sensitive monitoring of the treatment of osteoporosis.
为了基于对跟骨化学和微观结构（骨矿物质密度）信息的检测，研究联合功能光声（PA）和定量超声（US）诊断骨质疏松症的可行性。临床可用的用于诊断骨质疏松症的X射线或超声技术并未报告诸如化学信息和骨矿物质密度等重要参数。光声骨评估技术具有独特优势，包括对分子和代谢特性具有良好的敏感性，在临床转化方面具有巨大潜力。通过进行多波长光声测量，评估了人跟骨中的化学信息，包括矿物质、脂质、氧合血红蛋白和脱氧血红蛋白。同时，通过进行光声光谱分析，对作为重要骨物理特性的骨矿物质密度进行了量化。进行了非配对t检验和双向方差分析以比较两个受试者组的结果。多波长光声测量能够评估小梁骨中几种化学成分的相对含量，包括矿物质和有机物质，如氧合血红蛋白、脱氧血红蛋白和脂质，这些与代谢活动和骨骼健康相关。此外，骨矿物质密度的光声测量与双能X线吸收法显示出良好的相关性（高达0.65）。光声技术的化学和微观结构测量都可以区分两个受试者组。这项初步临床研究的结果表明，光声技术通过提供与骨骼健康相关的额外化学和微观结构信息，可能导致对骨质疏松症的准确早期诊断以及对治疗的敏感监测。
