基于光声的白血病临床前模型中小鼠股骨骨髓氧饱和度评估
Photoacoustic-based oxygen saturation assessment of murine femoral bone marrow in a preclinical model of leukemia.
作者信息
Wood Cayla, Harutyunyan Karine, Sampaio Diego R T, Konopleva Marina, Bouchard Richard
机构信息
Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
出版信息
Photoacoustics. 2019 Feb 20;14:31-36. doi: 10.1016/j.pacs.2019.01.003. eCollection 2019 Jun.
A variety of hematological diseases manifest in the bone marrow (BM), broadly characterized as BM failure (BMF). BMF can be caused by acute lymphoblastic leukemia (ALL), which results in an expansion of hypoxic regions in the BM. Because of this hypoxic presentation, there is potential for improved characterization of BMF through assessment of oxygenation in the BM cavity. Photoacoustic (PA) imaging can provide local assessment of intravascular oxygen saturation (SO), which has been shown to correlate with pimonidazole-assessed hypoxia. This study introduces an optimized PA imaging technique to assess SO within the femoral BM cavity through disease progression in a murine model of ALL. Results show a statistically significant difference with temporal changes in SO (from baseline) between control and diseased cohorts, demonstrating the potential of PA imaging for noninvasive, label-free monitoring of BMF diseases.
多种血液系统疾病在骨髓（BM）中表现出来，广义上被称为骨髓衰竭（BMF）。BMF可能由急性淋巴细胞白血病（ALL）引起，这会导致BM中缺氧区域的扩大。由于这种缺氧表现，通过评估BM腔内的氧合情况，有可能更好地对BMF进行特征描述。光声（PA）成像可以提供血管内氧饱和度（SO）的局部评估，已证明其与匹莫硝唑评估的缺氧情况相关。本研究引入了一种优化的PA成像技术，通过ALL小鼠模型中的疾病进展来评估股骨BM腔内的SO。结果显示，对照组和患病组之间SO（相对于基线）的时间变化存在统计学上的显著差异，证明了PA成像在无创、无标记监测BMF疾病方面的潜力。
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