Takahashi Y, Kusama S, Mai M, Ueno M, Ogino T, Ueda H, Sawaguchi K
Nihon Geka Gakkai Zasshi. 1986 Nov;87(11):1422-5.
We calculate the CEA doubling time of liver metastasis (13 cases) from colonic cancer and studied the factors influencing the growth rate. The doubling time of liver metastasis from colonic cancer ranged from 10 to 112 days (mean 57.8 +/- 35.4 days) was found significantly different among differentiations in histological type. Namely, the doubling time of poorly differentiated adenocarcinoma was shorter than that of well differentiated adenocarcinoma. Moreover the postoperative survival time (Y: months) was found to be significantly correlated with doubling time (X: days); Y = 0.155X + 4.452, r = 0.718, p less than 0.05. These results suggest that the growth rate calculated as CEA doubling time of cancer plays an important role in determining the degree of biological behavior in colonic cancer patients.
我们计算了结肠癌肝转移（13例）的癌胚抗原（CEA）倍增时间，并研究了影响生长速率的因素。发现结肠癌肝转移的倍增时间为10至112天（平均57.8±35.4天），在组织学类型的分化之间存在显著差异。也就是说，低分化腺癌的倍增时间短于高分化腺癌。此外，术后生存时间（Y：月）与倍增时间（X：天）显著相关；Y = 0.155X + 4.452，r = 0.718，p＜0.05。这些结果表明，以癌的CEA倍增时间计算的生长速率在确定结肠癌患者的生物学行为程度中起重要作用。
