人甲状旁腺激素基因在大鼠垂体细胞中的细胞特异性表达。
Cell-specific expression of the human parathyroid hormone gene in rat pituitary cells.
作者信息
Igarashi T, Okazaki T, Potter H, Gaz R, Kronenberg H M
出版信息
Mol Cell Biol. 1986 May;6(5):1830-3. doi: 10.1128/mcb.6.5.1830-1833.1986.
Abstract
The promoter region of the human parathyroid hormone gene was fused to the Escherichia coli neo gene and introduced into GH4C1 rat pituitary and human HeLa cells. Both TATA boxes of the human parathyroid hormone gene accurately directed transcription in GH4C1 cells; the parathyroid hormone promoter was inactive in HeLa cells.
摘要
将人类甲状旁腺激素基因的启动子区域与大肠杆菌新霉素基因融合，并导入GH4C1大鼠垂体细胞和人类HeLa细胞。人类甲状旁腺激素基因的两个TATA框在GH4C1细胞中准确地指导转录；甲状旁腺激素启动子在HeLa细胞中无活性。
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