Wang Fangfang, Xiao Lianghua, Zhang Huahua, Wang Yan, Zhong Lin, Feng Xinwei, Liu Jianping, Gong Xiangwen
Department of Nursing, The Fifth People's Hospital of Ganzhou, Ganzhou, China.
Department of Nephrology, The Fifth People's Hospital of Ganzhou, Ganzhou, China.
J Asthma. 2024 Apr;61(4):271-281. doi: 10.1080/02770903.2023.2272804. Epub 2023 Nov 2.
This study aimed to investigate the potential anti-inflammatory and antioxidant effects of apigenin in rats with acute lung injury (ALI). We also examined changes in levels of inflammatory and antioxidant factors after apigenin treatment in a rat model of ALI. We searched several databases, including PubMed, Scopus, EMBASE, Web of Science, ProQuest, and GoogleScholar, to retrieve relevant articles for our systematic review and meta-analysis.Five studies with 226 rat models of ALI were included in this study. We investigated inflammatory factors and oxidative stress with the corresponding 95% confidence interval in three groups: 1. Group1 (control vs. ALI), 2. Group2 (ALI vs. apigenin10), and 3. Group3 (ALI vs. apigenin20).
Estimating the correlation and 95% confidence intervals for the inflammatory agents and oxidative stress in the intervention group (ALI), compared with that in the control group, respectively (correlation: 0.194; 95% confidence intervals, 0.101-0.282, value = .001, z-value= 4.08) and (correlation: 0.099; 95% confidence intervals, 0.016-0.182, value = .020, z value= 2.325). Estimating the correlation and 95% confidence intervals for the inflammatory agents and oxidative stress in the intervention group (apigenin 10 mg/kg), compared with that in the control group (ALI), respectively (correlation: 0.476; 95% confidence intervals, 0.391-0.553, value = .001, z-value= 9.678) and (correlation: 0.415; 95% confidence intervals, 0.313-0.508, value= .001, z-value= 7.349).
Apigenin may have potential anti-inflammatory and antioxidant effects in rat models of ALI. However, the efficacy of apigenin as a therapeutic strategy requires further investigation through prospective controlled randomized trials.
本研究旨在探讨芹菜素对急性肺损伤（ALI）大鼠的潜在抗炎和抗氧化作用。我们还检测了在ALI大鼠模型中给予芹菜素治疗后炎症和抗氧化因子水平的变化。我们检索了多个数据库，包括PubMed、Scopus、EMBASE、Web of Science、ProQuest和GoogleScholar，以获取相关文章用于我们的系统评价和荟萃分析。本研究纳入了五项包含226个ALI大鼠模型的研究。我们在三组中研究了炎症因子和氧化应激及其相应的95%置信区间：1. 第一组（对照组与ALI组），2. 第二组（ALI组与芹菜素10组），3. 第三组（ALI组与芹菜素20组）。
分别估计干预组（ALI）与对照组相比炎症因子和氧化应激的相关性及95%置信区间（相关性：0.194；95%置信区间，0.101 - 0.282，P值 = 0.001，z值 = 4.08）和（相关性：0.099；95%置信区间，0.016 - 0.182，P值 = 0.020，z值 = 2.325）。分别估计干预组（芹菜素10mg/kg）与对照组（ALI）相比炎症因子和氧化应激的相关性及95%置信区间（相关性：0.476；95%置信区间，0.391 - 0.553，P值 = 0.001，z值 = 9.678）和（相关性：0.415；95%置信区间，0.313 - 0.508，P值 = 0.001，z值 = 7.349）。
芹菜素在ALI大鼠模型中可能具有潜在的抗炎和抗氧化作用。然而，芹菜素作为一种治疗策略的疗效需要通过前瞻性对照随机试验进一步研究。
