Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada.
Sexually Transmitted and Blood-Borne Infections, National Microbiology Laboratory at JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Canada.
Glob Public Health. 2023 Jan;18(1):2269435. doi: 10.1080/17441692.2023.2269435. Epub 2023 Oct 18.
Inferring HIV transmission networks from HIV sequences is gaining popularity in the field of HIV molecular epidemiology. However, HIV sequences are often analyzed at distance from those affected by HIV epidemics, namely without the involvement of communities most affected by HIV. These remote analyses often mean that knowledge is generated in absence of lived experiences and socio-economic realities that could inform the ethical application of network-derived information in 'real world' programmes. Procedures to engage communities are noticeably absent from the HIV molecular epidemiology literature. Here we present our team's protocol for engaging community activists living in Nairobi, Kenya in a knowledge exchange process - The CIPHR Project (Community Insights in Phylogenetic HIV Research). Drawing upon a community-based participatory approach, our team will (1) explore the possibilities and limitations of HIV molecular epidemiology for key population programmes, (2) pilot a community-based HIV molecular study, and (3) co-develop policy guidelines on conducting ethically safe HIV molecular epidemiology. Critical dialogue with activist communities will offer insight into the potential uses and abuses of using such information to sharpen HIV prevention programmes. The outcome of this process holds importance to the development of policy frameworks that will guide the next generation of the global response.
从 HIV 序列推断 HIV 传播网络在 HIV 分子流行病学领域越来越受欢迎。然而，HIV 序列通常是在远离受 HIV 流行影响的人群的情况下进行分析的，也就是说，没有涉及到受 HIV 影响最严重的社区。这些远程分析往往意味着，在没有生活经历和社会经济现实的情况下产生了知识，这些知识可以为网络衍生信息在“真实世界”计划中的伦理应用提供信息。参与社区的程序在 HIV 分子流行病学文献中明显缺失。在这里，我们介绍了我们团队在肯尼亚内罗毕的社区活动家参与知识交流过程的方案——CIPHR 项目（社区洞察 HIV 研究中的系统发育）。我们的团队将借鉴基于社区的参与式方法：（1）探索 HIV 分子流行病学对重点人群计划的可能性和局限性；（2）试点社区为基础的 HIV 分子研究；（3）共同制定关于进行伦理安全 HIV 分子流行病学的政策指南。与活动家社区的关键对话将深入了解使用此类信息来加强 HIV 预防计划的潜在用途和滥用。这一过程的结果对于制定政策框架具有重要意义，这些框架将指导下一代全球应对措施。
