康拉宾 A-D：来自 和 的四种单萜-查尔酮缀合物及其抗炎和细胞毒性活性。
Conarubins A-D: Four Monoterpene-Chalcone Conjugates from and Their Anti-inflammatory and Cytotoxic Activities.
机构信息
Faculty of Engineering and Food Technology, Hue University of Agriculture and Forestry, Hue University, Hue City 49000, Vietnam.
Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue City 49000, Vietnam.
出版信息
J Org Chem. 2023 Nov 3;88(21):15318-15325. doi: 10.1021/acs.joc.3c01825. Epub 2023 Oct 18.
Four novel compounds, conarubins A-D (-), were isolated from the whole plants of collected in Vietnam. Their structures were elucidated by extensive spectroscopic analyses and by quantum chemical calculations of NMR and ECD. Compounds and were the first examples of monoterpene-monoterpene-chalcone conjugates in nature, whereas compound was an unprecedented monoterpene-substituted chalcone containing a 3,4,5-trioxygenated cyclohexa-2,5-diene-1-one ring. The anti-inflammatory and cytotoxic activities of all isolates were investigated.
从越南采集的全株中分离得到了 4 种新型化合物，分别命名为 conarubins A-D(-)。通过广泛的光谱分析和 NMR 和 ECD 的量子化学计算，确定了它们的结构。化合物 和 是自然界中首次发现的单萜-单萜-查尔酮类化合物，而化合物 则是一种前所未有的含有 3,4,5-三氧代环己-2,5-二烯-1-酮环的单萜取代查尔酮。对所有分离物的抗炎和细胞毒性活性进行了研究。
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