从草豆蔻种子中分离得到的两种新型单萜-查尔酮共轭物。
Two novel monoterpene-chalcone conjugates isolated from the seeds of Alpinia katsumadai.
作者信息
Hua Shu-Zhen, Luo Jian-Guang, Wang Xiao-Bing, Wang Jun-Song, Kong Ling-Yi
机构信息
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Tong Jia Xiang, Nanjing, People's Republic of China.
出版信息
Bioorg Med Chem Lett. 2009 May 15;19(10):2728-30. doi: 10.1016/j.bmcl.2009.03.117. Epub 2009 Mar 28.
Three monoterpene-chalcone conjugates, including two novel compounds isorubraine (2) and sumadain C (3), and a known compound rubraine (1) were isolated from the seeds of Alpinia katsumadai. Their structures and relative configurations were established by NMR spectroscopy and X-ray crystallography. Cytotoxic activities of these compounds were evaluated against cell lines HepG2, MCF-7 and MAD-MB-435, and compound 3 exhibited potent cytotoxic activity.
从草豆蔻种子中分离出三种单萜-查耳酮共轭物，包括两种新化合物异红林（2）和苏马丹C（3），以及一种已知化合物红林（1）。通过核磁共振光谱和X射线晶体学确定了它们的结构和相对构型。评估了这些化合物对肝癌细胞系HepG2、乳腺癌细胞系MCF-7和黑色素瘤细胞系MAD-MB-435的细胞毒性活性，化合物3表现出较强的细胞毒性活性。
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