原癌基因和癌基因形式的c-H-ras DNA对人二倍体成纤维细胞的促有丝分裂作用。
Mitogenic effects of the proto-oncogene and oncogene forms of c-H-ras DNA in human diploid fibroblasts.
作者信息
Lumpkin C K, Knepper J E, Butel J S, Smith J R, Pereira-Smith O M
出版信息
Mol Cell Biol. 1986 Aug;6(8):2990-3. doi: 10.1128/mcb.6.8.2990-2993.1986.
Abstract
Nuclear microinjection of c-H-ras DNA induced DNA synthesis in reversibly nonproliferating quiescent human cells. The proto-oncogene and oncogene forms were equally effective inducers. In contrast, c-H-ras DNA either alone or in combination with the adenovirus E1A gene did not cause terminally nondividing senescent cells to synthesize DNA.
摘要
将c-H-ras DNA进行核显微注射可诱导可逆性非增殖静止人类细胞中的DNA合成。原癌基因形式和癌基因形式具有同等的诱导效果。相比之下，单独的c-H-ras DNA或与腺病毒E1A基因联合使用时，都不会使终末非分裂衰老细胞合成DNA。
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